University of California

University of Florida Research Foundation Inc

Biomolecular Research Institute Ltd.

Bachem Bioscience, Ing.

Katalin Kalman

George A Gutman

William Reade Kem

K George Chandy

Michael William Pennington

Raymond Stanley Norton

Kanianthara G Chandy

Grischa Chandy

Disclosed are methods and compositions comprising DNA segments, and proteins derived from sea anemone species. More particularly, it concerns the novel ShK toxin, ShK toxin analogs, chemically-modified toxin analogs, and nucleic acid segments encoding the ShK toxin from Stichodactyla helianthus. Various methods for making and using these DNA segments, DNA segments encoding synthetically-modified ShK toxins, and native and synthetic ShK peptides are disclosed, such as, for example, the use of DNA segments as diagnostic probes and templates for protein production, and the use of proteins, fusion protein carriers and peptides in various immunological and diagnostic applications.

ShK toxin compositions and methods of use

This disclosure relates to the identification of a new voltage-gated potassium channel gene, Kv1.7, which is expressed in pancreatic .beta.-cells. The invention utilizes this new potassium channel for assays designed to identify extrinsic materials with the ability to modulate said channel for the development of therapeutics effective in the treatment of non-insulin-dependent diabetes mellitus.

Voltage-gated potassium channel gene, KV1.7, vectors and host cells

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Irvine, CA, United States of America

Katalin Kalman