Egis Gyogyszergyar Rt.

Gis Gyogyszergyar Rt.

Katalin Horvath

Imre Moravcsik

Ferenc Andrasi

Tamas Hamori

Pal Berzsenyi

Istvan Gyertyan

Jozsef Reiter

Gabor Zolyomi

Pal Vago

Eszter Szentkuti

Anna Bakonyi

Edit Horvath

Gyorgyne Mate

Gyula Simig

Gabor Gigler

Istvan Gacsalyi

Gabor Blasko

Istvan Tarnawa

Andras Egyed

Istvan Ling

Sandor Solyom

Gyorgy Somogyi

Karoly Tihanyi

Melinda Gal

Marta Szollosy

Andras Bilkei-Gorzo

Emese Csuzdi

Judit Bajnogel

Gizella Abraham

Cecilia Salamon Haskane

Peter Korosi

Hilda Botka

Klara Daroczi Kazone

Erszebet Birkas

Peter Botka, Deceased

Jeno Korosi, Deceased

The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.

1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine

This invention relates to new 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.

1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives

Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions. A process to make the 2,3-benzodiazepine derivatives includes converting starting compounds which are substituted by one or two halogen groups and have the general formula ##STR2##

2,3-Benzodiazepine Derivatives as non-competitive AMPA

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Budapest, Hungary

Katalin Horvath