Richter Gedeon Vegyeszeti Gyar Rt

Biorex Kutato Es Fejleszto Rt

Biorex Research & Development Co.

Katalin Biro

Egon Karpati

Zoltan Tuba

Laszlo Szporny

Maria Marsai

Szabolcs Szeberenyi

Laszlo Jaszlits

Andrea Jednakovits

Mihaly Barabas

Sandor Gorog

Laszlo Vereczkey

Szaboles Szeberenyi

Erzsebet Radvanyi Nee Hegedus

Istvanne Udvardy Nagy

Istvanne Udvardy-Nagy

Erzsebet Radvanyne

Maria Lovas Nee Marsai

Miklos Riesz, Deceased

Laszle Szporny

Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions

Hydroximic acid derivatives, pharmaceutical compositions containing

New monoquaternary and diquaternary 5-alpha-hydroxy-3,16-diaminoandrostane salts are disclosed with curare-like muscle relaxant activity. The new salts are characterized by a surprisingly rapid onset time.

Diamino-androstane derivatives

The invention relates to new 3-amino-17a-aza-D-homo-5.alpha.-androstane derivatives of the general formula I ##STR1## wherein R.sub.1 represents a methylene or an &gt;N--CH.sub.3 group, and n stands for 1 or 2, and the acid addition salts and the quaternary salts of the general formula ##STR2## thereof, wherein R.sub.2 stands for an alkyl or alkenyl group having from 1 to 4 carbon atoms, and A represents a halogen atom, provided that if R.sub.1 stands for an &gt;N--CH.sub.3 group, R.sub.2 is attached to the nitrogen of that &gt;N--CH.sub.3 group. The new compound possess a non-polarizing neuromuscular blocking activity and have a short activity period.

3-Amino-17a-aza-D-homoandrostane compounds, and pharmaceutical

Curare-type salts of the formula ##STR1## wherein Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of

Diamino-androstanes and a process for the preparation of the said

Curare-type salts of the formula ##STR1## WHEREIN Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of

New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.

Triamino-androstanes and a process for the preparation of the said

Growing community of inventors

Budapest, Hungary

Katalin Biro