Medical Biological Laboratories Co., Ltd.

Nagoya University

Oncotherapy Science, Incorporated

Kasumi Yagi

Kenichiro Ono

Yusuke Nakamura

Shuichi Nakatsuru

Toyomasa Katagiri

Kenji Kadomatsu

Motoki Kuhara

Keigo Endo

Satoshi Kishida

An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-&#x3b1; protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-&#x3b2;1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activity of suppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

Antibody against human NRG1 protein

A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.

Monoclonal antibody against human midkine

The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.

Tumor-targeting monoclonal antibodies to FZD10 and uses thereof

Growing community of inventors

Tokyo, Japan

Kasumi Yagi