Council of Scientific and Industrial Research

Shantani Proteome Analytics Pvt. Ltd

Kashinath Komirishetty

Dumbala Srinivasa Reddy

Vasudevan Natarajan

Chaitanya Saxena

Siva Swaroop Pandrangi

Prakash Daulat Jadhav

The present invention provides novel tricyclic compound of Formula I or its stereoisomer or ester or pharmaceutically acceptable salts and preparation thereof useful for treatment of cancer.

Tricyclic compounds and preparation thereof

Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof

The patent discloses novel indazole compounds of general formula 1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications, cardiovascular dysfuntion or related diseases, pharmaceutical compositions comprising them and processes for their preparation. 

Indazole compounds and a process for the preparation thereof

The present invention relates to a simple, economical and short synthesis for the class of compounds chemically belonging to amino acrylic acids of general formula I exhibiting both antibacterial and anti-plasmodium (anti-malarial) activity, in good yield and purity. Process for the preparation of said compound comprising heating amine (A) and pantolactone or substituted pantolactone (B) in a solvent selected from cyclohexane, benzene, toluene, xylene, dipheny!ether; anisole, dioxane, etc. at a temperature in the range of 110-150&#xb0; C. for about 24 hrs followed by further raising the temperature of the mixture to a temperature in the range of 200-230&#xb0; C. for period in the range of 15 to 25 min followed by cooling the crude reaction mixture to room temperature to obtain compound of general Formula I. 

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Maharashtra, India

Kashinath Komirishetty