University of Michigan

The Ohio State University

Kashappa-Goud Desai

Steven Paul Schwendeman

Susan Regina Mallery

Gary D Stoner

Peter E Larsen

Susan R Mallery

Steven P Schwendeman

Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.

Controlled release mucoadhesive systems

Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.

Active self-healing biomaterial system

Growing community of inventors

Ann Arbor, MI, United States of America

Kashappa-Goud Desai