University of California

Karyn Newman

Jay D Keasling

Eric M Paradise

Dae-Kyun Ro

Mario Ouellet

Rachel Eachus

Kimberly Ho

Timothy Ham

Steven E Lindow

The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprising a subject nucleic acid or recombinant vector. The present invention further provides a transgenic plant comprising a subject nucleic acid. The present invention further provides methods of producing an isoprenoid compound, the method generally involving culturing a subject genetically modified host cell under conditions that permit synthesis of an isoprenoid compound modifying enzyme encoded by a subject nucleic acid.

Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof

DSF-based microbial pathogens may be controlled by certain methods and compositions. A method of controlling diseases caused in a host organism by pathogenic microbial expression of &#x3b1;,&#x3b2; unsaturated fatty acid signal (DSF) molecules involves inoculating the host organism with a non-pathogenic microbe that disrupts &#x3b1;,&#x3b2; unsaturated fatty acid signal molecule-mediated cell-cell communication by the pathogenic microbe in the host organism. Microbes having protein expression that interferes with &#x3b1;,&#x3b2; unsaturated fatty acid signal molecule-mediated cell-cell communication by the pathogenic microbe in the host organism can be identified and isolated or engineered by transformation with DSF-interference (inhibition or activation) gene or genes. Genes conferring DSF-interference activity can also be expressed in organisms (e.g., plants) susceptible to diseases caused by microbes that use DSF, resulting in genetically resistant organisms.

Biological control of pathogenicity in microbes that use alpha, beta unsaturated fatty acid signal molecules

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Berkeley, CA, United States of America

Karyn Newman