University of Pennsylvania

Inovio Pharmaceuticals, Inc.

The Wistar Institute

Vgx Pharmaceuticals, Inc.

Karuppiah Muthumani

David B Weiner

Niranjan Y Sardesai

Jian Yan

Mathura P Ramanathan

Bernadette Ferraro

Patricia A Brown

Douglas R Kern

Seleeke Flingai

Rodney A Bowling

Donghui Zhang

Kate Broderick

Michele Kutzler

Joo-Sung Yang

Nyamekye Obeng-Adjei

Jewell Walters

Megan Wise

Veronica Scott

Emma L Reuschel

Daniel Choo

Andrew Y Choo

Geoffrey Ouma

Michael A Chattergoon

Emile Mohler

Nyameke Obeng-Adjei

Andrew K Choo

Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.

Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom

Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.

DNA antibody constructs encoding anti-ZIKV envelope antibodies

Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.

MERS-CoV vaccine

Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

Cancer vaccines and methods of treatment using the same

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.

DNA antibody constructs and method of using same

Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.

Immunogenicity of an optimized synthetic consensus DNA vaccine for porcine epidemic diarrhea virus

Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy

Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

Vaccines with biomolecular adjuvants

Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy

Growing community of inventors

Cherry Hill, NJ, United States of America

Karuppiah Muthumani