Abbvie Inc.

University of Minnesota

Katholieke Universiteit Leuven

Kartik Subramanian

Christopher Chumsae

Xiaobei Zeng

Diane D Dong

Wen Chung Lim

Kathreen A Gifford

Zehra Kaymakcalan

Hong Yang

Natarajan Ramasubramanyan

Matthew Omon Herigstad

Lihua Yang

Chee Furng Wong

Catherine M Verfaillie

Wei-Shou Hu

Mayda Perez Thiele

Ying Jing

Yonsil Park

Mayda Perez

The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.

Stem cell aggregates and methods for making and using

The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.

Methods to modulate lysine variant distribution

The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.

Cell culture methods to reduce acidic species

The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimental, are also provided.

Low acidic species compositions and methods for producing and using the same

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimental, are also provided.

Modulated lysine variant species compositions and methods for producing and using the same

The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.

Non-static suspension culture of cell aggregates

The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF&#x3b1; is detrimxental, are also provided.

Growing community of inventors

Northborough, MA, United States of America

Kartik Subramanian