Michigan State University

Karthik Sambanthamoorthy

Martin F Semmelhack

Christopher Waters

Matthew Neiditch

The various embodiments relate to a compound comprising: wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkoxy, aryloxy, heteroaryloxy, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, acyl, acylamino, amino, alkylamino, dialkylamino, arylamino, carboxylate (&#x2014;COH), cyano, nitro, &#x2014;CONH2, heteroarylamino, oxime, alkyloxime, aryloxime, amino-oxime or halogen when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are carbon, and X is O, NR (where R is hydrogen, alkyl, aryl or acyl), S, SO (sulfoxide), SO(sulfone), or C(R)(where R=H, alkyl, aryl, alkenyl, alkynyl, or acyl); or wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen or hydroxyl when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are each independently nitrogen, and compositions, combinations, pharmaceutically acceptable salts, esters, and prodrugs thereof. The invention also relates to methods of using such compounds and compositions.

Growing community of inventors

Lansing, MI, United States of America

Karthik Sambanthamoorthy