Handylab, Inc.

Bio-rad Laboratories, Inc.

Becton Dickinson and Company Limited

Celsee Diagnostics, Inc.

Venture Lending & Leasing Iv, Inc.

Venture Lending & Leasing V, Inc.

Karthik Ganesan

Kalyan Handique

Sundaresh N Brahmasandra

Gene Parunak

Betty Wu

Jeff Williams

Nikhil Phadke

Priyadarshini Gogoi

Kyle Gleason

Aaron Kehrer

Austin Payne

Vishal Sharma

Brian Boniface

Will Chow

Daniel M Drummond

Thomas Catalino Gubatayao

This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.

Integrated system for processing microfluidic samples, and method of using same

A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.

System and method for retrieving and analyzing particles

A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.

Processing particle-containing samples

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

Microfluidic system for amplifying and detecting polynucleotides in parallel

Systems and methods for performing simultaneous nucleic acid amplification and detection. The systems and methods comprise methods for managing a plurality of protocols in conjunction with directing a sensor array across each of a plurality of reaction chambers. In certain embodiments, the protocols comprise thermocycling profiles and the methods may introduce offsets and duration extensions into the thermocycling profiles to achieve more efficient detection behavior.

Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection

Integrated system for processing microfluidic samples, and method of using the same

Growing community of inventors

Ann Arbor, MI, United States of America

Karthik Ganesan