Abbott Gmbh & Co Kg

Pharmasol Gmbh

Karsten Mäder

Rainer Helmut Müller

Karsten Krause

Volkard Jenning

Andreas Lippacher

Volkhard Jenning

The invention relates to drug-free or drug-loaded lipid particles of a mixed matrix made of solid and liquid lipids, and to a method for producing highly concentrated lipid particle dispersions of solid-liquid particles having a lipid content of from 30% to 95% or a solids content of from 30% to 95% (lipid and stabilizer), which in contrast to biamphipileic cremes are integer particles, and/or which upon dilution of the highly concentrated particle dispersions with the outer phase result in free-flowable particle dispersions.

Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same

The invention relates to superfine microparticles and nanoparticles and a process for their gentle preparation with exclusion of water or minimization of water and/or exclusion of plasticizers and/or reduced temperature load, in which a matrix material is subjected to a high-pressure homogenization process in an anhydrous or water-poor medium and/or at low temperatures, preferably room temperature (20&#xb0; C.) and in particular below the freezing point of water, which leads to a gentle particle reduction with minimization of the impairment of the chemical stability of the homogenized material.

Method for controlled production of ultrafine microparticles and nanoparticles

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Berlin, Germany

Karsten Mäder