Vyzkumny Ustav Veterinarniho Lekarstvi, V.v.i.

Imuthes Limited

Institute of Organic Chemistry and Biochemistry Av Cr, V.v.i.

Karsten Hipler

Andrew David Miller

Jaroslav Turanek

Miroslav Ledvina

The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein RRRRand Rare each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; Ris a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; Rand Rare each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.

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Basel, Switzerland

Karsten Hipler