Qiagen Gmbh

Evotec Biosystems Ag

Medoderm Gmbh

Evotec Biosystems Gmbh

Olympus Corporation

New York University

Yale University

Evotec Oai Ag

Chemotherapeutisches Forschunginstitut Georg-speyer-haus

Transimmune Ag

Diagen Institut Fur Molekular-biologische, Diagnostik Gmbh

Ihf Institut Fur Hormon-und Fortpfianzungsforschung Gmbh

Oiagen Gmbh

Evotec Biosystem Ag

Neurimmune Holding Ag

Karsten Henco

Manfred Eigen

Rudolf Rigler

Metin Colpan

Thomas Freier

Michael Stuke

Rivelino Montenegro

Wolfgang Simm

Ulo Mets

Jerker Widengren

Michael Brinkmeyer

Jan Grimm

Roger Nitsch

Richard L Edelson

Adrian Hayday

Michael Girardi

Helga Rubsamen-Waigmann

Marcel Maier

Petra Feuser

Hagen Von Briesen

Ursula Dietrich

Detlev Riesner

Rolf Guenther

Herbert Kuhnel

Andreas Immelmann

Michalina Adamski

Andreas Schwienhorst

John Holland

Anja Zeller

Olaf Lehman

Justin Duckworth

Christof Biebricher

Esteban Domingo

Robert Tigelaar

Gunter Bauer

Steffen Howitz

Robert E Tigelaar

Nicholas Hunt

Olaf Lehmann

Thomas Wegener

Björn F Lindemann

Rodney Turner

Bj&ouml;rn Lindemann

Kevan Willey

Heike Obermann-Pless

Arndt Stichel

Gerhard Steger

Günter Bauer

Juergen Rolf Mueller

Peter Axhausen

Guenter Bauer

The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.

Method for obtaining globally activated monocytes

A chitosan for use in an antimicrobial treatment of a patient's tissue and a pharmaceutical composition comprising a chitosan for use in an antimicrobial treatment of a patient's tissue. A method of treating a microbial infection, the method comprising the step of administering to a patient an effective amount of a chitosan and an aqueous solution comprising chitosan. A chitosan or a pharmaceutical composition comprising a chitosan for use in an epithelial cell growth stimulating treatment of a patient's tissue. A method of stimulating the growth of epithelial cells the method comprising the step of administering to a patient or to an epithelial cells containing cell culture an effective amount of a chitosan or a pharmaceutical composition comprising chitosan. A tissue dressing material characterized in that it consists of chitosan or a chitosan comprising composition.

Antimicrobial and/or epithelial cell growth stimulating substance and composition and tissue dressing material

A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.

Method of providing patient specific immune response in amyloidoses and protein aggregation disorders

The present invention relates to methods for disinfecting or decontaminating a material or for preventing an infection or contamination of a material. The invention further relates to compositions which are suitable for disinfecting a material or for preventing an infection or contamination of a material and to uses of such compositions. The invention further relates to a medical use of chitosan and to a pharmaceutical composition comprising the chitosan. The invention further relates to a method of treating a microbial infection and to an aqueous solution comprising chitosan. The invention moreover relates to a chitosan or a pharmaceutical composition comprising a chitosan for an epithelial cell growth stimulating treatment of a patient's tissue and to a method of stimulating the growth of epithelial cells. The invention also relates to a tissue dressing material.

Compositions and methods for disinfecting materials

A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.

A Method for identifying one or a small number of molecules, especially in a dilution of &#x2266;1 &#x3bc;M, using laser excited FCS with measuring times &#x2266;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &#x2266;10l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably &#x2267;1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 &#x3bc;m from the observation objective.

Method and a device for the evaluation of biopolymer fitness

The invention relates to a method for optically detecting at least one entity which is arranged on a substrate. The at least one entity is scanned with a measuring volume using at least one radiation source and a confocal optic. During a scanning process an auxiliary focus is generated by means of at least one second radiation source and a second optic. Radiation generated by the first radiation source is collimated by a first optic and radiation generated by the second radiation source is collimated by a second optic. A retroreflection from the auxiliary focus is detected by at least one detector and is used to measuring the position of an interface and, thus, for indirectly positioning the measuring volume. The position of the auxiliary focus relative to the measuring volume is adjustable in a defined manner.

Scanning microscopic method having high axial resolution

A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system,

Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena

The method according to the invention permits a selected withdrawal of one or a few molecularly disperse or cellular components of a system, such as molecules, molecular complexes, vesicles, micelles, cells, optionally together with an associated volume element V having a size of 10l&#x2267;V&#x2267;10l from a larger sample volume. The selected transfer of the sought component to another environment is effected by defining the space and time of withdrawal by means of a signal correlating with the small component to be withdrawn. The method is particularly useful for the withdrawal of non-abundant components the existence of which can be detected in a preceding step by a scanning process. The method is also useful for the withdrawal of per se unidentified components.

Method and device for the selective withdrawal of components from complex mixtures

A method for identifying one or a small number of molecules, especially in a dilution of &lE;1 &mgr;M, using laser excited FCS with measuring times &lE;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &lE;10 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.

A micromechanical ejection pump for extracting small fluid volumes from a flowing sample fluid is provided with a substrate, and a canal for pressurized working fluid. The micromechanical ejection pump also has a canal for ejecting a fluid volume from the sample fluid. The working fluid canal runs into the extension of the sample fluid canal discharging crosswise thereto. The ejection canal connected to the sample fluid canal branches off from the working fluid canal opposite to the sample fluid canal. The working fluid canal and the ejection canal have in particular a substantially similar cross-section of 0.01-0.12 mm,, wherein the ratio of the cross-section of the sample fluid canal to the cross-section of the working fluid canal or the ejection canal is preferably between 0.2 and 0.5, more particularly between 0.3 and 0.4 and most preferably 0.35.

Micromechanical ejection pump for separating small fluid volumes from a flowing sample fluid

Growing community of inventors

Dusseldorf, Germany

Karsten Henco