Lts Lohmann Therapie-systeme Gmbh

Lts Lohmann Therapie-systeme Ag

Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Karsten Cremer

Bodo Asmussen

Karin Ludwig

Hans-Rainer Hoffmann

Walter Muller

Michael Roreger

Klaus Schumann

Peter Steinborn

Walter M&uuml;ller

Dieter Anh&auml;user

Uwe Bungarten

A primary packaging unit for film-like or wafer-like administration forms for oral application with an off-cut of an upper web of packaging material and of an lower web of packaging material is characterized in that a plurality of dosage units of a film-like or wafer-like administration form, individually sealed in flat compartments formed without cold or hot forming of the packaging material and spaced at a distance to one another, are present in a primary packaging unit, and there are perforations between the compartments which enable the separation of individual compartments, if necessary.

Primary packaging unit for film-like or oblate-like administered shapes

In a solid medicament form for the peroral application of active agents containing a uniform distribution of active agent in a polymer material, the polymer material is in the form of flat fragments.

Solid medicament form with active agent distributed in flat polymer fragments

The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.

Expandable gastro-retentive therapeutic system with controlled active substance release in the gastro-intestinal tract

A pharmaceutical lozenge for the modified release of active compounds in the gastrointestinal tract is described, with active-compound-containing particles which have a first coating controlling the release and a further, outer coating with saliva-resistant properties. The first coating, which controls the release of active compound, can have release-delaying or enteric properties.

Lozenge for the modified releasing of active substances in the gastrointestinal tract

A dry-coated tablet for controlled release of active substance, having an erodible core tablet (,) containing at least one active substance, and a substantially erosion-resistant shell consisting of a dry-coated layer (,), is characterized in that the dry-coated layer (,) has at least one opening (,), and one end of the core tablet (,) extends as far as the opening (,).

Laminated tablet with pointed core

An oral preparation, comprising at least one pharmaceutical active compound in a matrix which is swellable in aqueous medium, which is released from the matrix into the aqueous medium in a delayed manner on swelling thereof, while the matrix is largely resistant to disintegration during the release process, it is characterized in that it is a layered tablet with layers adhering to one another, of which at least one layer is the swellable matrix layer and at least another layer is an auxiliary and/or excipient layer, and in that the swellable matrix layer contains an amount of crosslinked amylose.

Oral preparation containing at least one active pharmaceutical substance in a matrix capable of swelling in an aqueous medium

Layered tablet for the controlled release of active substances

Oral administration form having acid active substances and a process for

A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.

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Bonn, Germany

Karsten Cremer