Johnson and Johnson Vision Care, Inc.

University of Illinois

Karson S Putt

Randall Braxton Pugh

Edward R Kernick

Sharika Snook

Camille A Higham

Frederick A Flitsch

James Daniel Riall

Paul Joseph Hergenrother

Leslie A Voss

William Chester Neeley

Dwight Abouhalkah

Daniel B Otts

Quinn Patrick Peterson

Valerie Fako

Douglas Lilac

Rahul Palchaudhuri

Michael Ferran

Katherine Rowan Hardy

Terry O'Brien

Vitaliy Nesterenko

Daniel Preza

Adam Toner

Andres F Arrubla

Edward R Kemick

Brittany Joy Allen

Robin Shane Dothager

Benjamin James Leslie

Grace W Chen

Jennifer M Pearson

Compositions and methods relating to induction of cell death such as in cancer cells are disclosed. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds in connection with modification of procaspases such as procaspase-3 are disclosed. In various embodiments, the compounds and compositions are capable of activation of procaspase-3.

Compounds and methods for the treatment of cancer

The present invention provides methods for forming an ophthalmic lens that can include a media insert and/or electronic components. In particular, the present disclosure provides for adhesion promoting functionalization steps for a biocompatible coating to bind a hydrogel material to a plastic surface or electronic component prior to the polymerization of the hydrogel. In some aspects, the media insert can be used to contain energy sources and/or functional electronic components which may be, for example, in a stacked integrated component configuration to permit a generally arcuate shape that can conform to the anterior surface of an eye.

Method of manufacturing hydrogel ophthalmic devices with electronic elements

The present invention described a system for an energized ophthalmic device with a media insert that includes microfluidic elements upon or within the media insert. In some embodiments, the microfluidic elements may be useful for the purpose of analyzing an analyte such as glucose in a fluid sample. In addition, some embodiments can function with a medicament administering device to treat an abnormal condition identified during the analyte analysis in the fluid sample.

Ophthalmic lens with a microfluidic system

The present invention, as described above and as further defined by the claims below, provides methods for forming an Ophthalmic Lens that encapsulates a Rigid Insert, wherein the Rigid Insert may be tailored to correct specific astigmatic characteristics of an eye and apparatus for implementing such methods, as well as Ophthalmic Lenses formed with the Rigid Inserts.

Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

The present invention discloses methods and apparatus for methods and apparatus for manufacturing an Ophthalmic Lens with passive event coloration mechanisms, which may not require a power source. In some embodiments, the passive event coloration mechanisms may be combined with Rigid Inserts or Media Inserts, wherein the inserts may provide additional functionalities.

Ophthalmic apparatus with a passive event-based coloration system

The present invention discloses methods for manufacturing and programming an energizable Ophthalmic Lens with a programmable Media Insert. In some embodiments, a Media Insert may be programmable to allow for further customization of the energized Ophthalmic Lens. The Media Insert may be programmed prior to or during the manufacturing process. Alternatively, the Media Insert may be programmed after the components have been encapsulated, wherein the programming may occur wirelessly. Accordingly, methods of wirelessly programming the Media Insert may be significant.

Methods for manufacturing and programming an energizable ophthalmic lens with a programmable media insert

The present invention describes single-piece or multi-piece Rigid Inserts that may be included in an Ophthalmic Lenses or may comprise the Ophthalmic Lens, wherein the Rigid Insert may be formed through the processing of thin sheet material by thermoforming. Single piece annular Rigid Inserts may perform the function of providing a template for printed patterns to be included in Ophthalmic Lenses. Single piece full Rigid Inserts may perform the function of polarizing light or filtering light based on the properties of materials used to form the insert. Multi-piece Rigid Inserts may include activation and energization elements. The present invention also includes methods and apparatus for forming the Rigid Inserts.

Thermoformed ophthalmic insert devices

Method of manufacturing an ophthalmic lens with a passive event-based coloration system

The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting an ophthalmic lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Light emitting diode disinfection base for ophthalmic lenses

The present invention describes methods for creating Viewing Sets of Ophthalmic Lens with translation filters, including embodiments where the translation filters are included in an encapsulated Rigid Insert. The present invention also includes methods for forming a Media Insert capable of powering and controlling activation of an active translation filter, and more specifically, where the Media Insert may be incorporated in an Ophthalmic Lens Viewing Set.

Ophthalmic lens viewing sets for three-dimensional perception of stereoscopic media

The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a surface of the storage case. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Contact lens storage case surface disinfection

This invention discloses methods and apparatus for forming Ophthalmic Lenses with Stabilizing Features, and more specifically, Ophthalmic Lenses that include an encapsulated Insert Device.

Ophthalmic devices with stabilization features

The present invention provides a device for an energizable Ophthalmic Lens with an event coloration mechanism. The event coloration mechanism may color or change color based on some predefined event. For example, a predefined constituent or predefined condition of the tear fluid may be indicative of the predefined event, and the event coloration mechanisms may interact with the tear fluid, accordingly. The event coloration mechanism may provide the energizable functionality of the Ophthalmic Lens in some embodiments. In others, the event coloration mechanism may be passive but may interact and interface with the electrical components of the Ophthalmic Lens, such as, for example, those included within the Media Insert. Event coloration mechanisms may be combined with additional functionalities that may be included in an energizable Ophthalmic Lens.

Growing community of inventors

Jacksonville, FL, United States of America

Karson S Putt