Genentech, Inc.

Auckland Uniservices Limited

Karoly Nikolics

Peter David Gluckman

Peter H Seeburg

Keith C McFarland

Christopher Williams

Deborah L Segaloff

The invention relates to the purification, and cloning of receptors for the luteinizing hormone, choriogonadotropin, follicle stimulating hormone, and thyroid stimulating hormone. The invention additionally concerns the uses for such molecules in the diagnosis and therapy of human conditions.

Luteinizing hormone/choriogonadotropin (LH/CG) receptor

The invention relates to methods of treating injuries to or diseases of the central nervous system which methods involve increasing the active concentration(s) of transforming growth factor beta 1 (TGF-&bgr;1) and/or analogues thereof in the central nervous system of the patient. The present invention also provides pharmaceutical compositions comprising TGF-&bgr;1 and/or analogues thereof for administration to a patient prior to, simultaneous with, or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.

TGF-&bgr;1 to improve neural outcome

A method of treating injuries to or diseases of the central nervous system that predominantly affects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of increasing the active concentration(s) of insulin-like growth factor 1 and/or analogues thereof in the central nervous system of the patient. The present invention also provides therapeutic compositions comprising insulin-like growth factor 1 and/or analogues thereof for administration to a patient at or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.

IGF-1 to improve the neural condition

A method of treating injuries to or diseases of the central nervous system that predominantly effects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of increasing the active concentration(s) of insulin-like growth factor 1 and/or analogues thereof in the central nervous system of the patient. The present invention also provides therapeutic compositions comprising insulin-like growth factor 1 and/or analogues thereof for administration to a patient at or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.

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Belmont, CA, United States of America

Karoly Nikolics