Alkahest, Inc.

University of California

Leland Stanford Junior University

The Johns Hopkins University

Genentech, Inc.

The United States Government As Represented by the Department of Veterans Affairs

Auckland Uniservices Limited

Karoly Nikolich

Steven P Braithwaite

S Sakura Minami

Sam Jackson

Laura Corradini

Peter David Gluckman

Anton Wyss-Coray

Paul F Worley

Ian Gallager

Saul A Villeda

Anthony A Lanahan

Rohini Kuner

Joe McCracken

Bernhard Goetz

Holger Hiemisch

Sigrid Scheek

Eugene Zhukovsky

Vu Dang

David Bell

Laura Coradini

Joe Mccracken

Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.

Methods and compositions for treating retina-associated disease using CCR3-inhibitors

Methods of improving neurodegenerative disease with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount of the CCR3 modulating agent to the subject, with a concomitant improvement in cognition, motor, or other neurodegenerative-affected function. Cognitive and motor diseases upon which the methods of the invention can improve cognition include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, glaucoma, myotonic dystrophy, vascular dementia, progressive supranuclear palsy.

Methods and compositions for treating aging-associated impairments using CCR3-inhibitors

Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as neurocognitive disorders.

Blood plasma fractions as a treatment for aging-associated cognitive disorders

Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.

Methods and compositions for treating aging-associated impairments

A method of treating injuries to or diseases of the central nervous system that predominantly effects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of increasing the active concentration(s) of insulin-like growth factor 1 and/or analogues thereof in the central nervous system of the patient. The present invention also provides therapeutic compositions comprising insulin-like growth factor 1 and/or analogues thereof for administration to a patient at or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.

IGF-1 to improve neural outcome

The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

Immediate early genes and methods of use therefor

Growing community of inventors

Emerald Hills, CA, United States of America

Karoly Nikolich