Biogal Gyogyszergyar Rt.

Biogal Gyogyszergyar

B. Braun Melsungen Ag

Karoly Nagy

Bela Makadi

Valeria Szell

Agota Huelber Nee Dobos

Janos Erdei

Aniko Molnar Nee Antal

Bela Palotas

Karoly Buzasi

Eva Tomori Nee Joszt

Gyorgy Santha

Etelka Deli Nee Konszky

Kalman Polya

Imre Moravcsik

Gabor Ambrus

Istvan M Szabo

Attila Andor

Lajos Kiss

Karoly Albrecht

Eva Ilkoy

Antonia Jekkel

Laszlo Cseke

Antonia Jekkel Nee Bokany

Mihaly Kaszas

Kalman Konczol

Eva Toth-Sarudy

Ilona Varga

Agota Hulber Nee Dobos

Edit Halasz

Istvan Magyi

Andras Kiss

Vilma Szaszhegyesi

Istvan Mihaly

Istvan Mihaly Szabo

The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.

Microbial process for preparing mevinolin by a strain of aspergillus

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.

Microbial process for the production of immunosuppressive antibiotics

Growing community of inventors

Debrecen, Hungary

Karoly Nagy