Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Karoly Kanay

Gabor Kovacs

Sandor Virag

Istvan Stadler

Jozsef Ivanics

Geza Galambos

Gyorgy Dorman

Istvan Tomoskozi

Pal Hadhazy

Peter Gyory

Peter Kormoczi

Peter Kormoczky

Marianna Kovacs

Istvan Tomoskozy

Miklos Kiss

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;

Interfuranylene prostacyclins

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

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Ocsa, Hungary

Karoly Kanay