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Bruker Analytische Messtechnik Gmbh

Somalogic, Incorporated

Somalogic Operating Co., Inc.

Bruker Analytical Mebtechnik Gmbh

Karoly Holczer

Jason Paul Cleveland

Barry Patrick John Vant-Hull

Dieter Schmalbein

Michael E Stein

Peter Hoefer

John Koulakis

Viktor Ringeisen

Peter Hofer

Emil Kirilov

Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.

Proteomic assay using quantum sensors

A purpose of this invention is allow sensors to be placed at locations as close to a region of interest as possible, i.e. a few tenths of a millimeter from a probe, the target material and each other. The invention allows the user to reproduce and actively follow these locations from a remote location and at a distance, connected with to the locations with an arbitrary length of single mode optical fiber cable, and perform the sensor functions in a controlled environment using the sensor of choice without affecting the experiment.

Reproduction of nano movements at a distance

The invention describes a new method of tuning a Fabry-Perot resonant etalon, whose length is actively controlled through the frequency of an identical length microwave resonant cavity. The length is tunable over a several micron range with the precision and stability of the microwave source frequency.

Laser stabilization with an actively controlled fabry-perot resonance cavity

A method and an apparatus are disclosed for detecting an atomic structure of a sample along a surface thereof. The method comprises arranging the sample in a constant magnetic field (B.sub.0) of predetermined field strength and high homogeneity and irradiating a high-frequency magnetic field (B.sub.1) of a predetermined frequency on the sample, wherein the fields (B.sub.0) and (B.sub.1) are oriented perpendicularly to each other. The method further comprises providing a force-sensitive sensor having a paramagnetic tip comprising a paramagnetic material. The sensor is placed in close vicinity to the sample such that the paramagnetic tip is in atomic interaction with the sample surface which means that the distance between the tip and the surface is in the order of between 1 and 10 .ANG.. The predetermined field strength and the predetermined frequency are set such that electron paramagnetic resonance (EPR) is excited within the tip paramagnetic material. The paramagnetic tip is then displaced parallel to the sample surface for mapping predetermined points on the sample surface. During displacing the tip the force exerted on the tip by a local inhomogeneous magnetic field (B.sub.loc) caused by atomic magnetic moments (m.sub.e,k) of the sample is measured.

Magnetic resonance method and apparatus for detecting an atomic

A pulsed electron spin resonance spectrometer is provided with a first microwave oscillator for generating measuring signals of a high microwave frequency of about 80 GHz or above. A second microwave oscillator generates auxiliary signals at a lower microwave frequency of about 12 GHz or below. A first mixer generates mixed signals by mixing a measuring signal with an auxiliary signal. A pulse shaping channel generates pulsed mixed signals having a pulse length sufficient for carrying out pulsed electron spin resonance experiments. Moreover, a measuring resonator is provided to which the pulsed mixed signals are applied. A second mixer generates an output signals of a lower microwave frequency by mixing the mixed signal outputted from the measuring resonator with a signal being derived from the first microwave oscillator. A pulse shaping channel is switched between the second microwave oscillator and the first mixer.

Method of measuring pulsed electron spin resonance signals and pulsed

A method and a device for tuning a HF source, which oscillates at a basic frequency, to a narrow-band component, in particular for tuning a microwave source 61 of an electron spin resonance spectrometer to a resonator 62. In order to mutually tune the resonance frequency F.sub.R of the resonator 62 and the basic frequency f.sub.O of the source 61, the output signal of the source 61 is mixed in a mixer 64 with a sweep signal of an oscillator 65. The behavior of the resonator 62 is observed on a visual display unit 67, via a detector 68, in the form of what is called a 'mode curve', and the source 61 is re-tuned so that two dips in the mode curve are brought into coincidence.

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Los Angeles, CA, United States of America

Karoly Holczer