Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Karoline Droebner

Chantal Fuerstner

Pierre Wasnaire

Carsten Schmeck

Peter Kolkhof

Klemens Lustig

Hanna Tinel

Raimund Kast

Axel Kretschmer

Elisabeth Pook

Heiko Schirmer

Hartmut Beck

Jens Nagel

Thomas Neubauer

Lisa Dietz

Matthias Beat Wittwer

Timo Stellfeld

Thomas Mondritzki

Mark Meininghaus

Peter Hauff

Hana Cernecka

Joerg Mueller

Johanna Anlahr

Michaela Bairlein

Hannah Joerissen

Clemens-Jeremias Von Buehler

Anja Buchmueller

Sonja Anlauf

Ursula Krenz

Carsten Terjung

Marie-Pierre Collin-Kroepelin

Marie-Pierre Collin

Norbert Witowski

Uwe Muenster

Guillaume Levilain

Robert Fricke

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Prodrugs of substituted triazole derivatives and uses thereof

The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof

The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.

Substituted-arylethyl-2-arylquinoline-4-carboxamides and use thereof

The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Amide-substituted pyridinyltriazole derivatives and uses thereof

Growing community of inventors

Velbert, Germany

Karoline Droebner