Massachusetts Institute of Technology

Karolina Corin

Shuguang Zhang

Alexander Rich

Yael Gregory Maguire

Andreas Mershin

Asmamaw T Wassie

Patrick J Moran

David Kong

Lotta T Tegler

Lotta Tolstoy Tegler

The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing residues leucine (L), isoleucine (I), valine (V), and phenylalanine (F) in hydrophilic surface &#x3b1;-helical positions b, c, and f but not positions a, d, e, and g within the-transmembrane &#x3b1;-helical domain of the GPCR with glutamine (Q), threonine (T), threonine (T), and tyrosine (Y), respectively.

Water soluble membrane proteins and methods for the preparation and use thereof

In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.

Methods and apparatus for artificial olfaction

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.

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Cambridge, MA, United States of America

Karolina Corin