Polymun Scientific Immunbiologische Forschung Gmbh

Polymun Scientific Immunobilogische Forschung Gmbh

Polymun Scientific Immunbiogische Forschung Gmbh

Karola Vorauer-Uhl

Hermann W Katinger

Andreas Wagner

Guenter Kreismayr

Claus Riedl

Eckhard Furnschlief

Gunter Kreismayr

The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof

The invention relates to a device for producing lipid vesicles, which is equipped with a line () for transporting a polar liquid phase, with a line () for transporting an organic liquid phase containing lipids, with a collecting receptacle () for accommodating produced lipid vesicles, and with means for conveying the liquid phases through lines () and (). At at least one location, the outer side of line () forms a common contact surface with line () inside of which a common opening () is provided that permits the flow of liquid and joins the inside of line () to the inside of line (). Lines () and () do not contain agitating or dispersing aids in the area of the opening (). The invention also relates to a method for the careful production of lipid vesicles, wherein the lipid phase is sprayed under pressure perpendicular to the direction of flow of the polar phase and into the same, whereupon lipid vesicles having a narrow size distribution form spontaneously and without the action of mechanical agitating or dispersing aids.

Method and device for producing lipid vesicles

Superoxide dismutase (SOD), preferably rhSOD, is used in liposomes, optionally mixed with hyaluronic acid and/or at least one physiologically acceptable carrier, and other optional additives, to prepare a pharmaceutical composition useful against increased concentrations of superoxide radicals and/or the damage caused thereby. The compositions are administered topically, preferably as gels or ointments, to prevent and/or heal human fibrotic tissue degeneration diseases, in particular induratio penis plastica (Peyronie's Disease).

Liposomal recombinant human superoxide-dismutase for the treatment of peyronie's disease

Application of SOD in liposomes

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Vienna, Austria

Karola Vorauer-Uhl