Alza Corporation

Karly S Wang

James L Osborne

Melinda K Nelson

Wouter E Roorda

James A Hunt

Fred P Ehnow

Sharon M Fujita

Estela Basso

The present invention is directed to erodible delivery devices and to the compositions comprising the devices. The devices comprise (a) a body formed of a bioerodible polymer or polymers together with a required excipient not generally considered to be a pore-former ('required excipient'), and (b) an active agent. The agent is released from the device at a controlled rate and in a therapeutically effective amount, with the rate being primarily independent of the erosion rate of the polymer. The rate of release of the active agent from the polymeric compositions of the present invention is significantly increased over the rate of release dependent on erosion of the polymer matrix. The invention makes possible the increased control over and improved reproducibility of the release profile of the agent from the polymer. The invention is further directed to a method of delivering to an environment of use an active agent, which method comprises placing an appropriately sized and shaped delivery device of the above description in the environment of use.

Bioerodible devices and compositions for diffusional release of agents

An in-line adhesive, useful for transdermal delivery devices comprising a mixture of high and low molecular weighted polyisobutylene having a ratio HMW PIB:LMW PIB in the range of about 5-40:95-60 which is substantially free of plasticizers and tackifiers is disclosed. The adhesive finds particular use as a component of a transdermal delivery device for delivering oily non-polar agents such as nicotine, benztropine, secoverine, dexsecoverine, and arecoline.

Polyisobutylene adhesives for transdermal devices

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Newark, CA, United States of America

Karly S Wang