Bayer Aktiengesellschaft

Siemens Healthcare Diagnostics Gmbh

Miles Inc.

Bayer Materialscience Ag

Mannesmann Aktiengesellschaft

Bayer Intellectual Property Gmbh

Covestro Deutschland Ag

Miles Laboratories, Inc.

M2p-Labs Gmbh

Engelmann, Helmut

Hildenbrand, Karlheinz

Junkers, Gunter

Karlheinz Hildenbrand

Rolf Dhein

Hermann Perrey

Klaus Wehling

Guido Hennig

Friedrich-Karl Bruder

Wilfried Haese

Herbert Hugl

Rafael Oser

Dittmar Nerger

Rainer Protte

Wolfgang Fischer

Rudolf Merten

Michael J Pugia

Alexander Meyer

Jan Weikard

Knud Reuter

Kirkor Sirinyan

Gerhard D Wolf

Ralf Dujardin

Ulrich Von Gizycki

Bernhard Schulte

Wolfgang Zarges

Peter Capellen

Werner Hoheisel

Horst Brandt

Jacques Deprez

Claus Burkhardt

Willi Meister

Holger Ohst

Lloyd S Schulman

Hans-Ulrich Siegmund

Frank Buckel

Werner Kroll

Spencer Lin

Dietrich Tegtmeyer

Heinz-Dieter Brandt

Gunter Junkers

Alexander Riebel

Berit Krauter

Christoph Braden

Christoph Petry

Raymond Wong

Ice Zhang

Helmut Engelmann

Hans Franssen

Hans-Hagen Von Dohren

David Sherman

Ronald Helmut Stocker

Georg Frank

Niklas Frische

Stephan Schwers

Thomas Doege

Philip R Strom-Jensen

Eberhard Koch

Dirk Pfenning

Jan Wiekard

Ralf Friedricsen

Joerg Wehrle

Constantin Schwecke

Elke Reifenberger

Alexander Kremers

Helmut Krülls

Rüdiger Hahn

Andreas Müller

A method for producing silicate-containing magnetic particles having a closed and tight silicate layer and high purity. In addition, the novel method prevents an uncontrolled formation of aggregates and clusters of silicates on the magnetite surface, thereby having a positive influence on the properties and biological applications. The method enables depletion of nanoparticulate solid substance particles on the basis of a fractionated centrifugation. The silicate-coated magnetic particles exhibit optimized magnetization and suspension behavior as well as advantageous run-off behavior from plastic surfaces. These highly pure magnetic particles coated with silicon dioxide are preferably used for isolating nucleic acids from cell and tissue samples, whereby the separating out from a sample matrix ensues by means of magnetic fields. The particles are particularly well suited for the automatic purification of nucleic acids, mostly from biological body samples for the purpose of analyzing them with different amplification methods.

Magnetic particles with a closed ultrathin silica layer, method for the production thereof and their use

This invention relates to an optical recording medium in which at least a recording layer and a light transmitting layer are sequentially formed on a substrate and in which the light is illuminated from the light transmitting layer side for recording and/or reproducing information signals, said substrate comprising an injection molded part, and said substrate having a Young's modulus E of at least 2.15 GPa and a Q factor of lower than 160 measured at 25&#xb0; C. at 2000 Hz in accordance to ASTM E 756-05 05 and a transcriptability of the pit/groove structure of &#x3e;85%.

Disc shaped high density recording medium

Nanoparticles having a hydrophilic surface coatings having biological, molecular biological, biochemical and medical applications, and method for their production.

Hydrophilic nanoparticles with functional surface groups, production and use thereof

Magnetic particles for nucleic acid isolation are coated with silica and separated from impurities and nanoparticulates using a multi-step fractionation process. In each cycle of the fractionation process, the particles are stirred, sedimented, and resuspended, resulting in a decline in pH of the suspended particles. Repeating the fractionation process until the resuspended particles have dropped to a target pH in the range of about 9 to 10.5, and their zeta potential is more negative than about &#x2212;40 mV, results in a purified population of particles with a high and reproducible binding capacity for nucleic acids. The silica-treated magnetic beads produced by the method offer improved sensitivity and consistency for recovery of nucleic acids in a sample.

Silica magnetic particles with a high nucleic acid binding capacity

The present invention relates to a UV-crosslinkable composition comprising a) unmodified, protonated silica nanoparticles; b) urethane acrylate; c) polar solvent; and d) UV initiator system, wherein the amount by weight of unmodified, protonated silica nanoparticles exceeds the content of urethane acrylate and is at least 50.1 wt. %, based on the dry weight of the coating, to the use of the composition in the coating of substrates, and to substrates coated with such formulations.

Silica-containing UV-crosslinkable hardcoat coatings comprising urethane acrylates

Optical recording mediums comprising a substrate and a recording layer and a light transmitting layer sequentially disposed on the substrate; wherein the substrate comprises one or more parts selected from the group consisting of injection molded parts, injection molded sandwich structures having a molded surface layer and a molded core layer or two injection molded parts which are UV-bonded, and combinations thereof; and wherein the substrate has a Young's modulus E of at least 2.15 GPa and a Q factor of lower than 160 measured at 25&#xb0; C. at 2000 Hz in accordance to ASTM E 756-05.

Disc-shaped high-density recording mediums

A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.

Liquid permeable composition in dry reagent devices

The present invention relates to the use of graphite nonwovens and graphite woven fabrics for removing cellular constituents from blood and corresponding test agents for analysis of blood constituents.

Graphite nonwovens as functional layers in diagnostic test kits

The present invention describes electrochemical sensors, preferably electrochemical biosensors, in which the reference electrode and the measuring electrode are separated from one another by a porous, electrically nonconductive sheet material.

Electrochemical sensors having improved selectivity and enhanced

The novel process for working up solutions or suspensions of organic synthesis products having a pH value of &lt;3, preferably &lt;1, is carried out with the aid of an asymmetrical, semipermeable membrane composed of cyclic polyureas with repeating structural units of the formula (I) ##STR1## wherein the substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y and the index n are each as defined in the description.

Process for purifying organic synthesis products

Immunodiagnostic tests in which enzymes or antibodies are bound to porous carrier materials can be carried out by employing as porous carrier materials macroporous polymer membranes which are prepared by (a) dispersing an insoluble filler in a solution which contains at least two incompatible polymers in amounts which lead to phase separation in the solution, resulting in a homogeneous casting solution, and (b) applying this solution to a support and carrying out a precipitation coagulation.

Method for carrying out immunodiagnostic tests

An electrochemical sensor having at least two electrodes that communicate with a liquid measurement cell electrolyte and a housing that encloses the electrodes and the electrolyte. The surfaces of the electrodes facing the electrolyte bridge web connecting the electrodes are covered with a semipermeable membrane.

Electrochemical sensor

Asymmetric semipermeable membranes which consist of aromatic polycondensates having recurring units of the formula

Asymmetric semipermeable membranes of aromatic polycondensates,

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Krefeld, Germany

Karlheinz Hildenbrand