Technische Universitäet Wien

Karlheinz Hilber

Marko Mihovilovic

Xaver Koenig

Michael Schnuerch

Thomas Linder

Agnes Mike

Moumita Koley

A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently &#x2014;NR&#x2014;or &#x2014;O&#x2014;, Ris hydrogen or C-alkyl; Ris hydroxy, C-alkyl, C-alkoxy, carboxy, C-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C-alkylamino, or di-C-alkylamino, the C-alkyl or -alkoxy residue being optionally substituted with one or more Rsubstituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; Ris hydrogen, aryl, heteroaryl, or C-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more Rsubstituents, and where the C-alkyl is optionally further substituted with one or more Rsubstituents; and Ris selected from hydrogen, halo, NRR, OR, SR, and R, where the same options apply for Ras for R; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.

Triazine derivatives as differentiation catalysts

Provided are compounds of formula (I) and/or salts thereof, of the class of substituted pyridines and pyrimidines, useful for inducing cardiomyogenesis, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.

Substituted pyridines and pyrimidines

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Vienna, Austria

Karlheinz Hilber