Degussa Aktiengesellschaft

Degussa - Huls Ag

E.i. Dupont De Nemours and Company

Evonik Degussa Gmbh

Other

Degussa-huels Aktiengesellschaft

F. Hoffmann-la Roche Ag

Ciba-geigy Corporation

California Institute of Technology

Kernforschungsanlage Julich

Asta Medica, Aktiengesellschaft

Gesellschaft Fur Biotechnologische Forschung Mbh (gbf)

Degussa Akteingesellschaft

Degussa Aktiengellschaft

Degussa Aktiengesellchaft

Karlheinz Drauz

Andreas Bommarius

Matthias Kottenhahn

Axel Kleemann

Hans-Peter Krimmer

Michael Schwarm

Andreas Sebastian Bommarius

Matthias Schafer

Maria-Regina Kula

Christoph Weckbecker

Jurgen Martens

Hans Hilpert

Christian Wandrey

Paul Knochel

Armin Boerner

Fritz Wagner

Horst Bethge

Wonpyo Hong

Balreddy Kamireddy

Viacheslav Alexandrovich Petrov

Uwe Dingerdissen

Werner Hummel

Thomas Tacke

Renat Kadyrov

Wolfgang Leuchtenberger

Steven Henry Swearingen

Thomas Riermeier

Udo Kragl

Dieter Seebach

Franz Effenberger

Axel Monsees

Herbert Tanner

Klaus Huthmacher

Frances H Arnold

Klaus Deller

Peter Ackermann

Werner Schwarze

Kai Rossen

Hanspeter Fischer

Horst Weigel

Matthias Beller

Armin Börner

Gunter Knaup

Olaf Burkhardt

Stefan Verseck

Oliver May

Klaus Stingl

Ingo Klement

Hans Henniges

Ulrich Groeger

Andreas Karau

Jean-Louis Philippe

Hermann Lotter

Kyriakos Makryaleas

Roland Moller

Guenter Knaup

Juan Jose Almena Perea

Jens Holz

Michael Kraft

Carsten Bolm

G&uuml;nter Knaup

Hans-Dieter Jakubke

Jens Woeltinger

Frank Hubner

Stefan Buchholz

Michael Karrenbauer

Claus Rehren

Gerhard Sator

Harald Gröger

Eric Deguyon Taylor

Gerard Richet

Helfried Neumann

Markus Eckert

William Thomas Zimmerman

Paul Scherberich

Wallace C Petersen

Thomas Geller

Katharina Landfester

Guido Giffels

Rolf Wirthwein

Josef Altenbuchner

Dietmar Reichert

Robert J Turner

Marc Samson

Elfriede Sextl

Christoph Syldatk

Elisabeth Wolf-Heuss

Meir Lahav

Kofi S Amuti

Silvia Werner

Helge Werner

Dieter Most

Bernd Lehmann

Stefan Stockhammer

Hans Remmel

Oliver Meyer

Hans-Albrecht Hasseberg

Stefan Merget

Harald Groeger

David Zbaida

mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.

Mutants for the preparation of D-amino acids

The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed miniemulsions. The invention also relates to an enzymic reaction mixture which exhibits a miniemulsion.

Enzyme reactions in miniemulsions

A process for the preparation of an enantiomerically enriched amine, is performed by a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; or b) reacting an amine with an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically enriched amine; and c) separating the enantiomerically enriched amide from the enantiomerically enriched amine, wherein the acyl donor is a sulphonylacetic acid ester. The process (1) leads to high enantioselectivities, and (2) high reactivities, (3) is based on an acyl donor accessible in a simple manner, (4) is suitable for a large number of very different substrates and/or (5) is suitable for carrying out at high substrate concentrations.

Preparation of enantiomerically enriched amines and amides by enzymatic resolution using a sulfonylacetic acid ester as acyl donor

The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

Coupled cofactor-dependent enzymatic reaction systems in aqueous media

The present invention relates to ligands of the general formula (I). In addition, a process for the production thereof and the use thereof are demonstrated.

Bisphosphines as bidentate ligands

The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.

Process for the production of amino acids

The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connection with the production of enantiomerically enriched amino acids from racemic hydantoins.

Screening process for hydantoin racemases

Process for the racemization of N-protected amino acids using racemase

The present invention relates to an amidase enzyme, nucleic acids encoding the amidase, as well as methods of employing the nucleic acids and/or amidase to produce, for example, enantiomericallyenriched compounds such as D-amino acids.

Amidase from variovorax

The present invention is directed to a method for producing amino acids by reacting halogenated carboxylic acid ester (haloacid esters) with a metal cyanate in the presence of an alcohol and by subsequent acidic saponification of the urethane carbonic acid formed. The method is characterized by the metal cyanate being placed at an elevated temperature in an organic solvent and the other reactants being continuously charged into the mixture over a defined time period.

Method of producing amino carboxylic acids

The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the &ldquo;shrinking men&rdquo; phenomenon cam be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.

Amino acid composition for hemodialysis

Process for the preparation of allysine acetal

The present invention relates to a new D-carbamoylase and the gene sequences which code for this from the organism DSM 20117. Plasmids, vectors, microorganisms, particular primers and specific possible uses of the enzymes according to the invention are also mentioned. The invention moreover describes a new process for the discovery of enzymes which can be employed in a process for the preparation of D-amino acids starting from 5&prime;-substituted hydantoins.

Arthrobacter D-carbamoylase and methods of preparing enantiomerically enriched D-amino acids

The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the &ldquo;shrinking men&rdquo; phenomenon can be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.

Growing community of inventors

Freigericht, Germany

Karlheinz Drauz