Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Karlheinz Baumann

Thomas Luebbers

Synese Jolidon

Anja Limberg

Alexander Flohr

Erwin Goetschi

Helmut Jacobsen

Hasane Ratni

Werner Neidhart

Roland Jakob-Roetne

Andrew William Thomas

Guido Galley

Luke Green

Georg Jaeschke

Henner Knust

Rosa Maria Rodriguez Sarmiento

Bjoern Bartels

Rosa Maria Rodriguez-Sarmiento

Björn Bartels

The present invention relates to compounds of formula  The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

Bridged piperidine derivatives

The present invention relates to a compound of formula wherein The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

The invention relates to compounds of formula wherein the substituents are as described in claim. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

Modulators of amyloid beta

The present invention relates to compounds of formula I hetaryl I, hetaryl II, R, R, R, Y,m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

The invention relates to compounds of formula where hetaryl I, hetaryl II,

Heteroaryl substituted piperidines

The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically effective amount of a compound of formula I whereinR, R, R, V, W, Y, and Z are as defined herein or a pharmaceutically active acid addition salt of such compounds. The invention also relates to a subgenus of such compounds and pharmaceutical compositions containing them, as well as methods for their manufacture.

Heterocyclic gamma secretase modulators

The invention relates to compounds of formula wherein R, R, R, R, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

Modulators for amyloid beta

The invention relates to compounds of formula wherein hetaryl I, hetaryl II, and Rare as described herein. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease.

Growing community of inventors

Efringen-Kirchen, Germany

Karlheinz Baumann