Boehringer Mannheim Gmbh

Karl-Wolfgang Knitsch

Joachim Ziegenhorn

Albert Roder

Ulrich Neumann

Alexander Hagen

Helmut Determann

Eberhard Munz

Werner Kramer

Werner Zwez

A reconstitutable dry reagent for the turbidimetric determination of lipase, which reagent forms an emulsion upon adding water and comprises substrate oil, protective colloid, emulsifier and activator; and the process for making said dry reagent comprising preparing an aqueous emulsion of a triglyceride containing bile acid salt, colipase, at least 10% by weight of protective colloid, and at least a part of a preserving agent, lyophilizing the emulsion, mixing the lyophilizate with a buffer substance and urea, and recovering said dry reagent.

Reagent for the determination of lipase and process for preparing same

Porous tablets are produced by mixing the tablet components with a liquid solvent which is inert towards the components of the tablet and which freezes at a temperature from about -30 to +25.degree. C, the solvent constituting about 5 to 80% by weight of the total mixture, introducing the mixture into an inert cooling medium at a temperature low enough to solidify the solvent, pressing the mixture including the solidified solvent into tablets at a temperature below the freezing point of the solvent, and then evaporating the solvent from the tablets. Advantageously the solvent is water, cyclohexane, benzene and/or tert.-butanol, optionally containing alcohol. The tablets readily disintegrate in liquid.

Production of porous tablets

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Starnberg, Germany

Karl-Wolfgang Knitsch