Roche Diabetes Care, Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

F. Hoffmann-La Roche Ag

Karl Werner

Paul J Galley

Ulrich Porsch

Morris J Young

Alan Greenburg

Stefan Weinert

Steven Bousamra

Juergen Rasch-Menges

John F Price

Heino Eikmeier

P Douglas Walling

Peter Blasberg

Hans List

Joachim Hoenes

Volker Zimmer

Thomas Z Harkin

Blaine Edward Ramey

Michael J Celentano

Nader Afshar

Birgit Kraeling

Jason Bush

Bruno Robert Thoes

Richard W Wilson

Robert Lorenz

Kai-Oliver Schwenker

Stefan Riebel

Joerg Scherer

Klaus Thome

Gertrud Albrecht

Peter Seelig

Michael Lee Long

Ralf Schmitz

Stacia R Davis

Peter Stephan

Edgar Baumann

Wolfgang Obermeier

Ulf Meiertoberens

Bettina Steiner

Wen Tsung Wang

Wolfgang Rödel

Christian Niesporek

Wilfried Muller

Liang Yi Li

Rebecca Holliday

A portable analytical device includes a housing, a measuring facility and a processor in the housing, and an electrical connector having one end electrically connected to the processor and an opposite end operatively connectable to an external electronic device. The measuring facility is configured to analyze a change in a test element resulting from receipt thereon of a liquid sample of a body fluid and to generate measuring values resulting from the analysis. A memory has instructions stored therein executable by the processor to process the measuring values to generate analytical measuring data based thereon and to output the generated analytical measuring data onto the electrical connector. The analytical device does not include an intrinsic user interface for displaying the generated analytical measuring data. Display of the generated analytical measuring data is implemented exclusively by the external electronic device having received the generated analytical measuring data via the electrical connector.

Portable analytical device

A blood glucose measuring device and method for transmitting measured bG values to an external device such as a computer with improved data integrity for greater reliability is disclosed. The measuring device comprises a measuring means for determining measured blood glucose values, a measured value memory in which the measured blood glucose values are stored, a data interface that is configured for a data exchange with an external data reading apparatus, and a data file system which comprises a data reading application which can be accessed by the external data reading apparatus in order to read the stored measured blood glucose values, wherein the data system file further comprises a test application that is configured to execute an integrity test for the data reading application by forming a current digital signature for the data reading application and comparing this with a digital test signature provided in the data file system.

Blood glucose measuring device with reliable transmission of values to an external device

Embodiments of a testing method for diabetics to optimize their administered insulin dosage comprise collecting sampling sets of biomarker data, each sampling set comprising a sufficient plurality of non-adverse sampling instances and each sampling instance comprising an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when biomarker sampling parameters fall within the target biomarker range.

Systems and methods for optimizing insulin dosage

Disclosed is a test tape device comprising a housing having a cassette compartment for a replaceable tape cassette, a cassette door which can be retained in a closed position and which allows access to the cassette compartment through a housing opening in an open position, a tip cover which can be positioned in a first position covering a housing aperture and a second position allowing access to a tip of the tape cassette, wherein the tip cover is moveable to a third position in which the cassette tip is at least partially uncovered and the housing opening is extended into the area of the cassette tip, and wherein the cassette door is self-opening when moving the tip cover to the third position.

Test tape device and operating method

Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.

A portable analytical device includes a housing, a measuring facility and a processor in the housing, and an electrical connector coupled to the housing and having one end electrically connected to the processor and an opposite end extending outwardly from the housing. The measuring facility is configured to analyze an optical or electrochemical change in the test element having received a liquid sample of the body fluid and to generate measuring values resulting from the analysis. A memory has stored therein software at least a portion of which is executable by the processor to process the measuring values to produce analytical measuring data taking into account calibration values. The electrical connector may be a male universal serial bus (USB) electrical connector, a Type-A USB electrical connector or a mini-USB electrical connector having electrical connections for electrical power, ground, data and ID.

A portable analytical device is provided for analysis of a component of a body fluid. A measuring facility within the device may carry out the analysis on a test element inserted therein. The test element may contain a reagent that reacts with a liquid sample of the body fluid when the test element is contacted thereby to produce a change that is characteristic of the analysis. A processor may process measuring values determined by the measuring facility to yield analytical measuring data taking into account calibration values. A standardized, wire-based computer interface may be provided on the analytical device via which the analytical device can be operated by a computer, the analytical measuring data can be transmitted from the analytical device to the computer, the analytical device can be supplied with electrical power by the computer, and the analytical device can provide software to be read-out by the computer.

A device is provided for determining blood glucose characteristics including a display configured for presenting a graphical representation of a plurality of measurements of blood glucose values, wherein the graphical representation comprises a trend indicator indicating an approximate value trend in the sensed blood glucose value over a recent series of measurements, based on graphical segments having different graphical styles assigned to different ranges of sensed blood glucose values to indicate a transition from a first range to a second range of sensed blood glucose values. An associated method for operating a device for determining blood glucose characteristics is also provided.

Device and method for determining blood glucose characteristics

An analysis system is provided which comprises an integrated analysis device and a test strip magazine, for determining an analyte in a body fluid, wherein the analysis system comprises a first group comprising reusable components and a second group of components comprising a plurality of disposable articles. The second group includes non-electronic and electronic components, with critical interfaces configured between two or more such components, wherein non-electronic components can be disconnected from electronic components at a disconnection point. In one embodiment, critical interfaces are produced and tested during production of the analysis system.

Measurement system with distributed functions

A blood glucose test instrument kit having modular component parts capable of being assembled into a plurality of different handheld blood glucose test instruments is disclosed. The kit comprises the combination of an interconnection platform adapted to connect to a collection of interoperable modules. The collection of interoperable modules including: a plurality of different measurement engine modules, at least one user interface module, at least one power supply module. A handheld blood glucose test instrument is assembled by the interconnection to the interconnection platform of at least one measurement engine module, at least one user interface module, and at least one power supply module. The inter-module communication among the modules connected thereto to achieve enhanced glucose test instrument reliability by effecting at least one reliability protocol selected from a group of reliability protocols.

Blood glucose test instrument kit having modular component parts

Keypad for a portable electronic device

Glucose analysis instrument for diabetics, comprising a measuring device for determining glucose concentration values, a displaying device for displaying glucose concentration values, a signaling device for generating a reminder signal, and a control and evaluation device that comprises a processor and a data memory and is used to determine reminder times at which the signaling device is actuated. Event data are stored in the data memory, the event data containing information on events occurring in the life of a user of the glucose analysis instrument and on the time of occurrence of such events. The reminder times are determined by means of a reminder time determination algorithm taking into consideration event data from at least one previous day.

Glucose analysis instrument

A system for analysing a fluid sample arranged on a test element comprises a data processing unit configured to process results of an analysis of the fluid sample arranged on the test element, an audible signal generator, and a control unit. The control unit may control the audible signal generator to generate an audible test signal that is configured to test the operability of the signal generator to audibly encode information. The audible test signal may include audible features that allow for identification of any deviation of the generated audible test signal from a correctly generated audible test signal, and/or from which malfunction of the signal generator can be detected.

Method for the audible output of a piece of information in an analysis system

Method for monitoring insulin medication in which blood sugar values are determined before and after a meal. The difference between these measured values is plotted against a quotient calculated from the bread units ingested during the meal and the insulin units used to compensate for these bread units. Displaying many such points on a graph provides criteria for improving the insulin medication.

Method for monitoring insulin medication

Method of detecting and evaluating analog photometric signals in a test carrier analysis system, and apparatus for carrying out the method. The test field of a test carrier is irradiated by a light source clocked in light-dark phases. The reflected light is detected by a measurement receiver over a measurement period having several light-dark phases, and integrated. An effective suppression of stray and secondary light, which permits measurement even without the hitherto conventional shielding from ambient light, is achieved by a method in which the sequence of the light and dark phases integrated over the measurement period is irregular in such a way that the Fourier-transformed frequency spectrum includes a large number of different frequencies. Each individual frequency therefore makes only a small contribution to the measurement result.

Light source pulsed with irregular pulse sequence in analog photometric

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Wiesloch, Germany

Karl Werner