Astra Aktiebolag

Astrazeneca Ab

Aktiebolaget Astra

Astra Ab

Karl Thomas Antonsson

Ruth Elvy Bylund

Nils David Gustafsson

Nils Olov Nilsson

Nils Olov Ingemar Nilsson

Nils O Nilsson

Pharmaceutical preparation containing an effective amount of acetylsalicylic acid and a compound of Formula I.A&#x2014;A&#x2014;NH&#x2014;(CH)&#x2014;B

Peptide derivatives

The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.

Method of thrombin inhibition

The invention relates to compounds of the formula

Peptide derivatives as kininogenase inhibitors

A method is disclosed for treatment or prophylaxis of venous thrombosis employing the peptide HOOC--CH.sub.2 --(R)Cgl--aze--Pab or a stereoisomer thereof or a physiologically acceptable salt thereof.

Method for treatment or prophylaxis of venous thrombosis

The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method for synthesizing serine protease inhibitors which utilizes the compounds.

Starting materials in the synthesis of thrombin and kininogenase

The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing thrombin and kininogenase inhibitors. The invention further concerns an improved method for synthesizing the inhibitors which utilizes the compounds.

Starting materials in the synthesis of thrombin and kinogenase inhibitors

The invention concerns the compound of the formula: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method for synthesizing serine protease inhibitors which utilizes the compounds.

Growing community of inventors

Lindome, Sweden

Karl Thomas Antonsson