Arcus Biosciences, Inc.

Karl T Haelsig

Manmohan Reddy Leleti

Jaroslaw Kalisiak

Brandon Reid Rosen

Kenneth Victor Lawson

Joel Worley Beatty

Samuel Lawrie Drew

Guillaume Mata

Balint Gal

Artur Karenovich Mailyan

Zhang Wang

Kai Yu

Matthew Epplin

Clayton Hardman

Jay Patrick Powers

Xuelei Yan

Debashis Mandal

Erick Allen Lindsey

Jenna Leigh Jeffrey

Yongli Su

Anh Thu Tran

Steven Donald Jacob

Tezcan Guney

Jeremy Thomas Andre Fournier

Hyunyoung Moon

Jeremy Fournier

The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.

Process for preparing tetralin compounds

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha

Compounds that inhibit HIF-2&#x3b1;, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2&#x3b1;.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2&#x3b1;

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Berkeley, CA, United States of America

Karl T Haelsig