Merck Patent Gesellschaft MIT Beschrankter Haftung

Karl Siegfried Boos

Dieter Lubda

Friedhelm Eisenbeiss

Bernd Wilmers

Richard Sauerbrey

Andreas Walfort

Eckhard Schlimme

The invention relates to improved chromatographic support materials, to the preparation thereof and to the use thereof as sorbent for chromatography. The particles of these materials have hydrophobic surfaces consisting of fatty acid esters in the pores and hydrophilic outer surfaces. The materials according to the invention permit direct separation of protein-containing samples by means of reverse phase methods.

Modified chromatographic support materials

Chromatographic support materials which are modified with 1-amino-(2'-nitrophenyl-5'-boric acid)-2-hydroxy-3-O-propyl groups are provided, as well as methods for their preparation and use in gel-permeation chromatography and/or in affinity chromatography.

Nitro-modified chromatographic support materials

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Gauting, Germany

Karl Siegfried Boos