Hoechst Aktiengesellschaft

Karl Schmitt

Irmgard Hoffmann

Werner Fulberth

Ulrich Schacht

Willi Stammberger

What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

Medicinal composition and its use as antidepressive agent

4-Phenyl-8-amino-tetrahydroisoquinolines of the formula ##STR1## in which R.sub.1 stands for bromine and R.sub.2 stands for hydrogen or both R.sub.1 and R.sub.2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.

Growing community of inventors

Munich, Georgia

Karl Schmitt