Nanosystems L.l.c.

Nanosystem L.l.c.

Nawosystems L.l.c.

Karl R Mueller

W Mark Eickhoff

David A Engers

Nanoparticulate crystalline drug substances formulated in an aqueos phase emulsified in oil, are able to be made at less than 1000 nm size and provide increased bioavailability and lymphatic uptake following oral administration.

Formulations of compounds as nanoparticulate dispersions in digestible

A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, hygroscopic sugar and sodium lauryl sulfate exhibit greatly reduced gastric irritation following oral administration and/or hastened onset of action due to the substantial redispersion of the solid formulation to nanoparticles in gastric fluid.

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Pexton, PA, United States of America

Karl R Mueller