Medtronic Vascular, Inc.

Karl Olney

Benjamin Wong

Wei Wang

Laura McKinley

Tracey Tien

Joshua Dudney

Kshitija P Garde

Paul Devereux

Elliot J Howard

Luke Lehmann

David Clarke

Yogesh Darekar

Ya Guo

Raymond Ryan

James R Keogh

Niall F Duffy

Kevin M Mauch

Carol Elsa Eberhardt

Marc A Anderson

Alexander J Hill

Grainne Teresa Carroll

Geoffrey Orth

Matthew Fleming

Marian Patricia Lally

Elizabeth A Schotzko

Jeffrey Madden

Ciaran McGuinness

Brian T McHenry

Taylor Winters

Edward Sarnowski

Laura Mckinley

Padraigh Jennings

Stephen Montgomery

Karina Doyle

Gerry Kearns

Constantino Fiuza

A 'dry' packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

Packaging for dry tissue prosthetic heart valve

Devices for, and methods of, compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8&#xb0; C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.

Prosthetic heart valve cooling

Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8&#xb0; C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.

Methods of transcatheter delivery of a prosthetic heart valve. A distal region of a guide member assembly is advanced into a heart of a patient. The distal region is docked to native anatomy of the heart. A delivery device, including a collapsed prosthetic heart valve, is advanced over the docked guide member assembly. The collapsed prosthetic heart valve is located at an implantation site. The prosthetic heart valve is deployed from the delivery device, and then the delivery device is removed from the patient. At least a portion of the guide member assembly is removed from the patient. In some embodiments, the docking structure is docked to one or more of native mitral valve leaflets, chordae in the left ventricle, or walls of the left ventricle as part of a transseptal mitral valve delivery procedure.

Prosthetic heart valve delivery systems and methods

Conditioned bioprosthetic tissues for forming prosthetic valves including a sheet of bioprosthetic tissue having a first major surface and a second major surface. The first major surface has a pattern including at least one depressed region and areas of relief adjacent to the at least one depressed region. The at least one depressed region has a first tissue density that is greater than a second tissue density of the areas of relief.

Bioprosthetic tissue for use in a prosthetic valve

A method of reinforcing or repairing a bioprosthetic tissue for use as a prosthetic valve leaflet. The method includes evaluating a bioprosthetic tissue, identifying a defect in the bioprosthetic tissue, and selectively applying an adhesive to a surface of the bioprosthetic tissue at the defect prior to implantation in a patient.

Bioprosthetic tissue repair and reinforcement

Methods of preparing a sheet of bioprosthetic tissue for use as a prosthetic valve leaflet are disclosed. A method includes positioning a sheet of bioprosthetic tissue across an engagement face of a first patterned substrate. The engagement face defines a pattern having at least one raised region and areas of relief adjacent the at least one raised region. The tissue is compressed against the engagement face to deform the tissue to a deformed state corresponding with the pattern.

Bioprosthetic tissue for use as a prosthetic valve leaflet and method of preparing

Growing community of inventors

Tustin, CA, United States of America

Karl Olney