Norton Healthcare Limited

Karl James Hewson

George Robert Michael Savell

George Bostock

James Davies

Oliver Hart

Joshua Arieh Shenker

Matthew Keith Fordham

Xorge Castro Pelayo

Matthew Alexander Morris

Jeremy James Robert Kooyman

James Alexander Davies

An injection device comprising a housing (), and a dose selector () operatively connectable to a dose indicator positioned within the housing. The dose selector and the dose indicator () are capable of cooperating to set a dose to be ejected from the injection device. The injection device further comprises a spring () capable of storing energy necessary for ejecting the dose from the injection device. The spring is locked to the dose indicator such that a charging force can be transferred from the dose selector to the spring via the dose indicator to increase the energy stored by the spring.

Dose setting and indicator mechanism

An injection device comprises a housing having a first longitudinal axis (L). The injection device further comprises a medicament cartridge holder and a drive assembly including a drive shaft. The drive shaft is arranged around the first longitudinal axis. The drive assembly is capable of providing an axial force for ejecting a dose of medicament from the injection device. The medicament cartridge holder and at least part of said drive assembly are arranged around a second longitudinal axis (LC) which is substantially parallel to but offset from the first longitudinal axis.

Dose delivery mechanism

An injection device comprising a housing () and a dose selector () to set a dose of medicament to be ejected from the injection device. A spring () coupled to the dose selector stores energy necessary for ejecting the dose from the injection device. A ratchet () arrangement is provided to rotationally couple a ratchet component and an internal surface of the housing in a coupled state and to allow relative rotation between the ratchet component and the internal surface of the housing in an uncoupled state. An over-torque feature () located between the dose selector and the spring is actuatable, when the rotation of the dose selector causes the charging force to exceed a defined limit, to reduce the charging force transferred from the dose selector to the spring. Both the ratchet component and the over-torque feature are provided on a single component ().

Dose setting mechanism

An injection device comprises a housing having a longitudinal axis, an axially-depressible dose button (), a dose indicator (), a dose setting mechanism operatively coupled to said dose indicator and capable of setting a dose to be ejected from the injection device and spring capable of storing energy necessary for ejecting the dose from the injection device. The spring () is coupled to the dose setting mechanism such that a charging force can be transferred from the dose setting mechanism to the spring to increase the energy stored by the spring. The dose setting mechanism comprises an assembly of three components, including: &#x2022;a ratchet ring () rotationally and axially locked with respect to said housing, the ratchet ring including a ratchet component; &#x2022;a drive plate () including a first set of splines forming a ratchet arrangement with said ratchet component; and&#x2022;a dose selector () capable of being rotated about said longitudinal axis with respect to said housing to set the dose and including splines for disengaging said ratchet arrangement. The ratchet component is capable of interacting with both the splines on the dose selector and the splines on the drive plate.

An injection device comprises a dose selector, rotatable by a user to set a dose to be ejected from the injection device and a drive assembly including a drive shaft () and a plunger element (), the drive assembly being capable of providing an axial force for ejecting a dose of medicament from a medicament container. A dose limit nut () is provided which is rotationally coupled to but not axially coupled to said drive shaft. The plunger element is threaded so that the dose limit nut is engaged with said plunger element via said thread, in order to guide relative axial movement between the dose limit nut and the plunger element. The dose limit nut is provided with dose limiting endstops which are capable of limiting axial travel of said dose limit nut with respect to said plunger element, so as to limit maximum and minimum doses of medicament which can be set by the user. In addition, the dose limit nut comprises a last dose rotary endstop feature which prevents further rotation of said dose limit nut with respect to said drive shaft so as to prevent the user setting a dose that is greater than an injectable volume of medicament remaining in said medicament container.

Dose limiting mechanism

An injection device comprising a housing having a longitudinal axis, a dose selector () capable of being rotated about said longitudinal axis with respect to said housing by a user to set a dose of medicament to be ejected from the injection device and a spring () capable of storing energy necessary for ejecting the dose of medicament from the injection device. The spring is coupled to the dose selector such that a charging force can be transferred from the dose selector to the spring to increase the energy stored by the spring. The injection device further comprises a ratchet arrangement () moveable between an engaged state in which the spring is limited from unwinding from a currently selected dose and a disengaged state in which the spring is able to unwind and a drive assembly including a plunger element () capable of providing an axial force for ejecting a dose of medicament from the injection device. The drive assembly further comprises a drive clutch () moveable from a disengaged state in which a force path from the spring to the plunger element is interrupted and an engaged state in which the drive assembly can provide the axial force for ejecting a dose of medicament from the injection device via said force path.

An injection device comprises a housing, a dose indicator positioned within the housing and a dose selector operatively connectable to the dose indicator. The dose selector and the dose indicator are capable of cooperating with one another to set a dose to be ejected from the injection device. The dose indicator comprises an odometer including: i. a units () wheel operatively connected to the dose selector so that rotation of the dose selector also rotates the units wheel, and ii. a tens wheel () selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. The dose indicator further comprises an axially-moveable shuttle lock () rotationally locked to the tens wheel and selectively engageable with the units wheel and the housing. The tens wheel is selectively engageable with the units wheel via said shuttle lock and, when the tens wheel is not engaged with the units wheel, the shuttle lock is rotationally locked to the housing.

Injection device with dose indicator mechanism

An injection device comprises a housing () having a longitudinal axis. The injection device further comprises a dose selector () capable of setting a dose to be ejected from the injection device and a dose indicator comprising a units wheel () operatively connectable to the dose selector so that rotation of the dose selector about the longitudinal axis also rotates the units wheel, and a tens wheel () selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. A biasing means biases the dose indicator axially-rearwardly in the housing. An internal surface of the housing is provided with a tens housing feature selectively engageable with the tens wheel to prevent rotation thereof. An internal surface of the housing is provided with a units housing feature capable of moving the units wheel axially-forward against said biasing means such that the units wheel engages and moves the tens wheel axially-forward and free of said tens housing feature so as to allow rotation thereof.

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Cambridgeshire, United Kingdom

Karl James Hewson