Basf Se Corporation

Astrazeneca Ab

Karl Hult

Bernhard Hauer

Cecilia Kvarnström Branneby

Christian Von Corswant

Erik Söderlind

Anders Hamberg

Anders Magnusson

Fredrik Viklund

The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived fromlipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.

Enzymatically catalyzed method of preparing mono-acylated polyols

New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH&#x2014;(CH)&#x2014;CH&#x2014;(CH)&#x2014;CO&#x2014;[&#x2014;O&#x2014;R&#x2014;]&#x2014;O&#x2014;RR&#x2014;O (I); wherein for example Ris methyl, Ris optionally substituted C-Cacyl, alkyl, or alkenyl, Ris ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them. 

Non-ionic surfactants for poorly soluble molecules

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Stockholm, Sweden

Karl Hult