Boehringer Ingelheim Kg

Boehringer Ingelheim Gmbh

Boehringer Ingelheim Zentrale

Karl-Heinz Weber

Gerhard Walther

Claus S Schneider

Erich Lehr

Franz J Kuhn

Dieter Hinzen

Werner Stransky

Helmut Ensinger

Albrecht Harreus

Gojko Muacevic

Wolfgang Troger

Wolf-Dietrich Bechtel

Wolf D Bechtel

Karin Boke

Karin Boke-Kuhn

Adolf Langbein

Ulrike Kufner-Muhl

Jorge Casals-Stenzel

Gunter Schingnitz

Adolf Bauer

Hubert Heuer

Franz Birke

Jorge C Stenzel

Peter Danneberg

Armin Fugner

Enzio Muller

Ulrike Kuefner-Muehl

Wilhelm Frolke

Franz-Josef Kuhn

Gerhard Waither

Gerhard Walther, Deceased

Karl-Heinz Pook

Armin F/u/ Gner

A hetrazepine of the formula given below and a pharmaceutical composition comprising a therapeutically effective amount of the hetrazepine and a pharmaceutically acceptable inert carrier are disclosed and are useful in treating disease in a warm-blooded animal induced by endogenously formed PAF; ##STR1## wherein the substituents are defined herein.

Acylamino-substituted hetrazepines

The present invention relates to thienodiazepines of formula Ib: ##STR1## wherein U, V, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. This invention also relates to processes for preparing these thienodiazepines and their use in pharmaceutical compositions with PAF-antagonistic activity.

Hetrazepinoid amides

The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.

Xanthine derivatives with adenosine-antagonistic activity

Bornyl xanthine derivatives with adenosine-antagonistic activity

New xanthine compounds of formula I: ##STR1## wherein the substituents are defined herein, which xanthines are useful as adenosine antagonists.

8-substituted 1,3-dialiphaticxanthine derivatives

Xanthines of the formula I ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group:

The invention relates to new tetrahydropyridine derivatives, processes for preparing them and their use as pharmaceutical compositions with cholinomimetic properties.

Tetrahydropyridine derivatives

The invention relates to new diazephines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, processes for preparing them and their use as pharmaceutical compositions useful for treating PAF-induced disease.

New diazepines substituted in the 6-position, processes for their

The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;

Methods of using new thieno-triazole-1,4-diazepino-2-carboxylic acid

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di-substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and

N-heterocyclic substituted -pyrrolidin-2-ones

The invention relates to new 1,4-diazepines of the general formula ##STR1## in which R.sub.1, R.sub.2 R.sub.3, X and A have the meaning indicated in the specification. The new compounds are intended for use for the treatment of pathological states and diseases in which PAF (platelet activating factor) is involved.

Substituted-1,4-diazepines

The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;

Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides

1-(benzyl or pyridylmethyl)-4 or 5-aminomethyl-pyrrolidin-2-ones

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;

1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic

The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;

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Gau-Algesheim, Germany

Karl-Heinz Weber