Bayer Aktiengesellschaft

Bayer Healthcare Aktiengesellschaft

Bayer Yakuhin, Ltd.

Karl-Heinz Wahl

Reinhold Gehring

Marc Nowakowski

Werner Heilmann

Jurgen Stoltefuss

Michael Negele

Alfons Grunenberg

Herbert Diehl

Mathias Berwe

Hans-Peter Wirges

Jan-Bernd Lenfers

Samir Samaan

Klaus-Peter Voges

Karl Rittner

The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I)characterized in that compounds of the formula (II)are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.

Process for the preparation of sulphonamide-substituted imidazotriazinones

The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.

Thermodynamically stable form of (R)-3-&lsqb;&lsqb;(4-fluorophenyl) sulphonyl&rsqb;amino&rsqb;-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (ramatroban)

The invention relates to a process for the preparation of nifedipine by the reaction of methyl 2-(2-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate and the use of the nifedipine thus prepared for the production of a medicament.

Process for preparing nifedipine

The present invention relates to 3-substituted quinoline-5-carboxylic acid derivatives and processes for their preparation.

3-substituted quinoline-5-carboxylic acid derivatives and processes for

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Odenthal, Germany

Karl-Heinz Wahl