Novartis Finance Corporation

United States of America, As Represented by the Secretary of Agriculture

Karl-Heinz Van Pee

Philip E Hammer

Stephen T Lam

James Madison Ligon

Dwight Steven Hill

Sabine Kirner

Thomas R Young

Kanniah Rajasekaran

Thomas E Cleveland

Jeffrey W Cary

Thomas J Jacks

The present invention provides a method of making plants resistant to plant pathogens by transformation of host cells with a nucleic acid encoding a nonheme haloperoxidase. Transgenic plants which express a nonheme chloroperoxidase thereby resulting in enhanced resistance to phytopathogens are provided.

Transformation of plants with a chloroperoxidase gene to enhance disease resistance

The present invention is directed to the production of pyrrolnitrin in a host via recombinant expression of the polypeptides needed to biologically synthesize pyrrolnitrin. Genes isolated from P. fluorescens, P. pyrrocinia, B. cepacia, and M. fulvus that encode polypeptides necessary to produce pyrrolnitrin are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize pyrrolnitrin from any organism capable of producing pyrrolnitrin. The isolated genes may be transformed and expressed in a desired host organisms to produce pyrrolnitrin according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of pyrrolnitrin.

Pyrrolnitrin biosynthesis genes and uses thereof

The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

Genes for the synthesis of pyrrolnitrin

Growing community of inventors

Bannewitz, Germany

Karl-Heinz Van Pee