Sanofi-a Ventis Deutschland Gmbh

Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Sanofi

Sanofi-aventis

Hoechst Marion Roussel Deutschland Gmbh

Karl-Heinz Baringhaus

Stefan Petry

Guenter Mueller

Klaus Weidmann

Martin Bickel

Georg Tschank

Norbert Tennagels

Hubert Heuer

Gerhard Zoller

Karl Schoenafinger

Gunter Muller

Reinhard Kirsch

Swen Hoelder

Heiner Glombik

Elisabeth Defossa

Werner Kramer

Andreas W Herling

Thomas Klabunde

Alfons Enhsen

Ulrich Werner

Hans-Joerg Burger

Volkmar Gunzler-Pukall

Gunter Müller

Manfred Seidel

Günter Müller

Norbert Tennangels

The present invention relates to 5-oxoisoxazole derivatives of the formula I, the pharmaceutically usable salts thereof and the use thereof as medicinal substances. 

5-oxoisoxazoles as inhibitors of lipases and phospholipases

The present invention relates to azolopyridin-3-one derivatives of the general formula (I) with the meanings specified in the description, to their pharmaceutically usable salts and to their use as drug substances. 

Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases

The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs. 

Indazole derivatives as inhibitors of hormone sensitive lipase

Disclosed are compounds of the general formula (I), with the definitions of the substituents Rto R, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL). 

Substituted N-aminomethylene sulfonamides, production and use thereof as medicaments

The invention therefore relates to compounds of the formula I in which the variables are as defined in the specification, to pharmaceutical compositions containing them and to their use for therapeutically lowering blood glucose levels.

Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1B (PTB1B) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes

The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives. The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.

Pyrimido[5,4-e][1,2,4]triazine-5-7-diones, processes for preparing them and their use

The invention relates to triazolopyridine derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments. 

Triazolopyridine derivatives as inhibitors of lipases and phospholipases

Disclosed are novel compound of formula I, As defined herein and their use as pharmaceutically active compounds for reducing blood glucose, and/or treating one or more of type II diabetes, disturbances of lipid and carbohydrate metabolism, arteriosclerotic manifestations, and insulin resistance.

Hydroxybiphenyl carboxylic acids and derivatives, method for producing the same and their use

The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments for lowering blood sugar levels and for prevention and treatment of diabetes. 

Substituted oxazolobenzoisothiazole dioxide derivatives method for production and use thereof

The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.

Substituted an unsubstituted benzooxathiazoles and compounds derived therefrom

Benzotriazoles of formula I in which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase.

Bicyclic inhibitors of hormone sensitive lipase

Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for lowering the blood glucose and for the prevention and treatment of diabetes.

Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use

Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use in medicaments

The invention relates to substituted and unsubstituted 3H-benzo&lsqb;1,2,3&rsqb;oxathiazole 2,2-dioxides, 1,3-dihydrobenzo&lsqb;1,2,5&rsqb;thiadiazole 2,2-dioxides and 1,3-dihydro-benzo&lsqb;c&rsqb;isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.

Growing community of inventors

Wolfersheim, Germany

Karl-Heinz Baringhaus