Deutsche Gold- Und Silber-scheideanstalt Vormals Roessler

Karl H Kingler

Fritz Stroman

Klause Thiemer

There are prepare half amides (semi-amides) of unsaturated aliphatic dicarboxylic acids of the formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of these together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or C.sub.1 -C.sub.4 alkyl groups and n is 0 or 1 and their salts with the proviso that in the case of the free acids N[2-(3-hydroxyphenyl)-2-hydroxyethyl]-maleic acid monoamide is excluded. The compounds have blood pressure raising activity and also have antidepressive activity.

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Munich, Georgia

Karl H Kingler