Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Innophore Gmbh

E. Hawle Armaturenwerke Gmbh

Karl Gruber

Anton Glieder

Wolfgang Skranc

Gerhard Führer

Christian Gruber

Roland Weis

Georg Steinkellner

Ruud Luiten

Franz Lehner

The invention relates to a method for determining catalophores including the steps of creating a point cloud database for target protein structures; creating a query point cloud; and searching said database with said query to thereby identify one or more catalophores.

Determining novel enzymatic functionalities using three-dimensional point clouds representing physico chemical properties of protein cavities

The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.

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Graz, Austria

Karl Gruber