Bayer Aktiengesellschaft

Karl-Georg Metzger

Wilfried Schrock

Hans-Bodo Konig

Uwe Petersen

Rainer Endermann

Klaus-Dieter Bremm

Thomas Schenke

Klaus Grohe

Hans-Joachim Zeiler

Andreas Krebs

Franz Kunisch

Thomas Philipps

Peter Stadler

Bernd-Wieland Kruger

Thomas Jaetsch

Ingo Haller

Michael Schriewer

Hans-Joachim Kabbe

Dieter Habich

Arnold Paessens

Martin Scheer

Stephan Bartel

Oswald Lockhoff

Burkhard Mielke

Eckart Voss

Heinz-Georg Wetzstein

Michael Stegemann

Stephan Schneider

Gert Streissle

Theo Schroder

Peter Taylor

The present invention relates to new 8-amino-10-(azabicycloalkyl)-pyrido�1,2,3-d,e!�1,3,4!benzoxadiazine derivatives of the general formula (I) ##STR1## in which the radicals R.sup.1 to R.sup.4, Z and X.sup.1 have the meaning given in the description, processes for their preparation and their use in antibacterial compositions.

8-amino-10-(azabicycloalkyl)-pyrido�1,2,3-d,e!�1,3,4!benzoxadiazine

The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.

Quinolonecarboxylic acids

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partly hydrogenated isoindolinyl ring, processes for their preparation and antibacterial agents and feed additives containing these compounds.

7-isoindolinyl-quinolone-carboxylic acid derivatives

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and feed additives containing them.

Quinolone- and naphthyridonecarboxylic acid derivatives

The invention relates to naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.

Naphthyridonecarboxylic acid derivatives

The invention relates to new 3-substituted cephalosporins, a process for their preparation and their use as medicaments, in particular as medicaments having antibacterial activitity.

3-Substituted cephalosporins, and their use as medicaments

The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.

7-azaisoindolinyl-quinolone-carboxylic acid derivatives

Compounds of the formula ##STR1## in which R.sup.1 represents an optionally substituted, straight-chain or branched, saturated, monounsaturated or polyunsaturated alkyl radical, an optionally substituted, saturated or one- or polyunsaturated cycloalkyl radical or an optionally substituted aryl radical or aralkyl radical,

Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates

Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.

Pseudotrissaccharides, a process for their production and their use as

The invention relates to new derivatives, substituted on one or more nitrogen atoms, of 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols, which include the gentamycins, sisomicin, verdamycin, tobramycin, the kanamycins, the antibiotics G-418, 66-40 B, 66-40 D, JI-20 B, JI-20 B and G-52, and the 5-epi-, 5-epi-amino-5-deoxy and 5-epi-azido-5-deoxy derivatives of these antibiotics and the metamycins, and furthermore to processes for the preparation of these derivatives and to pharmaceutical compositions which contain the derivatives of the above mentioned 4,6-di-(amino-glycosyl)-1,3-diamino-cyclitols or their pharmaceutically acceptable acid addition salts, and to their use as antibacterial agents.

N-Substituted amino glycoside compounds, their production, and their use

Penicillins of the formula ##STR1## or pharmaceutically acceptable non-toxic salts thereof, wherein C* is a carbon atom constituting a center of chirality;

Penicillins

A compound of the formula: ##SPC1## Or a pharmaceutically acceptable nontoxic salt thereof wherein

Arylmethyl- and cyclohexenylmethyl- penicillins, substituted on the .alpha.-carbon atom of the side chain by a 2,3-disubstituted imidazolidinylcarbamide or a 2,3-disubstituted imidazolidinylthiocarbamido group, or by the corresponding 2,3-disubstituted 1,3-diazacyclohexylcarbamido or thiocarbamido groups are anti-bacterial agents.

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Wuppertal, Germany

Karl-Georg Metzger