Bayer Aktiengesellschaft

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Rainer Endermann

Karl G. Metzger

Ingo Haller

Andreas Krebs

Thomas Schenke

Klaus Grohe

Uwe Petersen

Michael Schriewer

Hans-Joachim Zeiler

Karl G Metzger

Hans-Bodo Konig

Wilfried Schrock

Michael Preiss

Klaus-Dieter Bremm

Florin Seng

Kurt Ley

Peter Stadler

Michael Boberg

Gunter Schmidt

Rolf Angerbauer

Delf Schmidt

Stephan Bartel

Oswald Lockhoff

Gunter Benz

Michael Walkowiak

Klaus Dieter Bremm

Eckart Voss

Klaus G Stunkel

Jorg Pfitzner

Bernd-Wieland Kruger

Thomas Jaetsch

Dieter Habich

Peter Feyen

Manfred Plempel

Klaus Schaller

Wolfgang Hartwig

Thomas Philipps

Burkhard Mielke

Hans Disselnkotter

Theo Schroder

Joachim Mittendorf

Franz Kunisch

Hans-Christian Militzer

Michael Matzke

Martin Scheer

Wolfgang Krohn

Hans-Georg Opitz

Horst Weyland

Paul Naab

Hein-Peter Kroll

Gunther Kinast

Ekkehard Niemers

Yutaka Hayauchi

Volker Klimetzek

Dieter Arlt

Thomas Himmler

Hermann Hagemann

Engelbert Kuhle

Klaus Sasse

Rolf Grosser

Hans-Joachim Kabbe

Arnold Paessens

Herbert Voege

Hanno Wild

Gerd Fengler

Werner Frommer

Heinz-Georg Wetzstein

Michael Stegemann

Stephan Schneider

Gert Streissle

Helmut Brunner

Dietmar Schafer

Klaus Bauer

Wilfried Kaufmann

Stefan B Ohm

Gunther Schmidt

Klaus Groche

Klaus Crohe

Jurgen Dornhagen

Hans-Rudolf Pfaendler

Wolfgang Hartiwg

Klaus Grobe

Uwe Peterson

The invention relates to intermediate compounds for preparing novel quinolone derivatives- and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.

7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.

Quinolone- and naphthyridonecarboxylic acid derivatives

The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

Intermediates for

Process for the fabrication of a multi-blade tool

The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments, and to prevent contamination of materials such as wood and leather.

Method of preserving materials using

Quinolone--and naphthyridonecarboxylic acid derivatives

The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.

New Cyclopentane- or cyclopentene-beta-aminoacid derivatives and their isomers, acid additional salts and metal salt complexes have strong antimicrobial and broad-spectrum antimycotic acitivity. As antimycotics they are especially active against dermatophyte, and biphasic fungi. The new compounds are also low toxicity antibacterial agents, effective against Gram positive bacteria, including antibiotic-resistant strains. The new Cyclopentane- or cyclopentene-beta-aminoacid derivatives are useful in human or veterinary medicine for combating dermatomycosis or systemic mycosis or local or systemic bacterial infections. In addition, the new compounds can also be used as preservatives, especially for water, foods, or organic materials such as polymers, lubricants, paints, fibers, leather, paper or wood.

Cyclopentane- and -pentene-.beta.-amino acids

Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##

Preparation of 7-(3-amino- and

The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments.

##STR1## in which Z represents a residue of the structure ##STR2## A represents N or C--R.sup.5. The end products are antibacterially active.

Preparation of 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen, X.sup.2 is hydrogen, halogen, amino or other radical, R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical, R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.

7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic acid

Quinolone-and naphthyridonecarboxylic acid derivatives

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Wuppertal, Germany

Karl G Metzger