Boehringer Ingelheim Pharmaceuticals, Inc.

Karl G Grozinger

Karl D Hargrave

Julian Adams

John Robert Proudfoot

James T Oliver

Kollol Pal

Ernest Cullen

Wolfgang Eberlein

Wolfhard Engel

Gunther Schmidt, Deceased

Gunther Trummlitz

Amale A Hawi

Robert Rothlein

John P Devlin

Genus J Possanza

Clara K Miao

Ronald Faanes

An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.

Pharmaceutical suspension comprising nevirapine hemihydrate

A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme. ##STR1##

Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl

A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme. ##STR1##

Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and

A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.

Method for the preparation of 3-amino-2-chloro-4-methylpyridines

Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.

5,11-dihyro-6H-dipyrido[3,2-B:2',3'-e][1,3]diazepines and their use in

Racemic mixtures of 1-(S,R)-(2-pyridyl)-2-cyclohexylethylamine are separated into (+)-(S)-1-(2-pyridyl)-2-cyclohexylethylamine or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine by admixture with (+)- or (-)-3-bromocamphor-8-sulfonic acid. 1-(S)-(2-pyridyl)-2-cyclohexylethylamine is an intermediate in the preparation of leukotriene biosynthesis inhibitors.

Process for the preparation of pure enantiomers of

Disclosed are novel pyrido[2,3,-b][1,5]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection. ##STR1##

Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of

Disclosed are novel pyrido[2,3-b][1,4]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection. The compounds are of the class having the structure: ##STR1##

Pyridobenzo-and pyridiothieno-diazepines useful for the treatment of HIV

This invention relates to a novel method for preparing certain dipyrido-diazepines.

Method for the preparation of 5,11-dihydro-6h-dipyrido

Disclosed are novel dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the treatment of HIV-1 infection. An exemplary species is 6-chloro-11-cyclopropyl-4-methyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine , which has the following chemical structure: ##STR1##

Dipyrido[3,2-B:2 ',3'-E][1,4]Diaqzepines and their use in the treatment

5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in

Method for preparing 3-amino-2-chloro-4-alkylpyridines

Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.

Anti-inflammatory thienylbenzylamine compounds

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;

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Ridgefield, CT, United States of America

Karl G Grozinger