General Electric Company

Ge Healthcare Bio-sciences Ab

Cytiva Sweden Ab

Karl Ekstrom

Gustav Jose Rodrigo

Enrique Napoleon Carredano

Roger Nordberg

Jan-Erik Lynga

Henrik Sandegren

Torbjorn Blank

Klaus Gebauer

Patrik Berndt Akerstrom

Mikael Berg

Hakan Lundstrom

Mike Peters

Catalin Andrei

Tomas M Karlsson

Lisa Stack

There is provided a method of preparing a mixed liquid having a first property and a second property. The method includes providing a first set of liquids, a second set of liquids, and a third set of liquids. The method includes combining the provided sets of liquids. Further, the method includes varying at least one of the liquid flows of the first and second sets and at least one liquid flow of the third set to adjust the first property and the second property to their respective predetermined values in the resulting mixed liquid flow.

Method of preparing liquid mixtures

The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate outlet ports and the permeate connector channels provide fluidic communication between the permeate apertures and the permeate channel.

Distribution plate for crossflow filtration cassettes

A method for preparing a liquid flow having pre-defined characteristics by mixing liquid flows of at least two different component stock solutions with each other comprises the steps of determining a selected property value for one or more of the stock solutions by sensing, in a flow of each stock solution separately, at least one characteristic related to the property value for the stock solution, and based on the determined property value or values, mixing the stock solution flows in mixing ratios giving the desired mixed liquid flow. A system for carrying out the method comprises sensor means and a control unit, wherein the control unit is arranged to evaluate the characteristics sensed by the sensor means and provide relative ratios of stock solutions required to obtain a mixed liquid flow having the pre-defined characteristics.

Method and system for preparation of liquid mixtures

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Uppsala, Sweden

Karl Ekstrom