Rohm Pharma Gmbh

Other

Rohm Gmbh

Rohm Gmbh Chemische Fabrik

Karl-Dieter Voelger

Ernst Mutschler

Heinrich Knauf

Christian Rietzel

Klaus Lehmann

Klaus Lossnitzer

Ilse Treudler

Erwin Wolf

Werner Moehrke

Ulrich Borchard

Albrecht Fleckenstein

Johanna Janke

Pteridine compounds, useful as diuretics, of the formula ##STR1## wherein R.sub.1 and R.sub.2 taken alone are, independently of each other, hydrogen, alkyl having from 1 to 6 carbon atoms, or benzyl, or wherein R.sub.1 and R.sub.2, taken together with the nitrogen atom to which they are bound, form a five- or six-membered heterocyclic ring system or such a ring containing one or two further hetero atoms, or wherein R.sub.1 and R.sub.2 together with the nitrogen are ##STR2##

Pteridine compounds

The present invention relates to pharmaceutical preparations with cardiac, particularly anti-arrhythmic activity. These preparations comprise, as an active principle, at least one compound of formula I: ##STR1## where R represents a lipophilic radical. The pharmaceutical compositions may comprise this compound in the presence of other pharmaceutical excipients and adjuvants.

2,4,7-triamino-6-phenylpteridine

What is disclosed is a method for the treatment of Parkinsonism or of psychic disturbances in a patient suffering therefrom, which method comprises orally or parenterally administering to said patient an effective amount of an active agent selected from the group consisting of (+)-trans-2-phenylcyclopropyl amine and physiologically acceptable acid addition salts thereof, said agent being essentially free of the corresponding (-)-enantiomer and its salts.

Treatment of Parkinson's disease

Pharmaceutical compositions having a diuretic effect and containing as the active ingredient a compound of the formula ##STR1## wherein R is hydrogen, a pharmaceutically acceptable cation, methyl, or a hydrophilic group R', are disclosed, as are novel compounds wherein R is R'.

Substituted pteridine compounds and pharmaceutical compositions

A cardio-protective pharmaceutical composition is disclosed, which composition comprises an inert carrier and a pharmaceutically-effective amount of a combination of 2,4,7-triamino-6-phenyl-pteridine (triamterene) and a calcium antagonist, such as .alpha.-isopropyl-.alpha.-[(N-methyl-N-homoveratryl)-.gamma.-aminopropyl]- 3,4-dimethoxyphenyl-acetonitrile-hydrochloride (verapamil).

Cardio-protective pharmaceutical composition

A pharmaceutical composition for inducing diuresis, which composition comprises a diuretically-effective amount of the sulfuric acid half ester of 2,4,7-triamino-6-p-hydroxyphenyl pteridine or of a physiologically tolerable salt thereof in combination with a pharmaceutical carrier.

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Bickenbach, Germany

Karl-Dieter Voelger